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Cellosaurus COLO 775 (CVCL_1996)

[Text version]

Cell line name COLO 775
Synonyms COLO-775
Accession CVCL_1996
Resource Identification Initiative To cite this cell line use: COLO 775 (RRID:CVCL_1996)
Comments Problematic cell line: Contaminated. Shown to be a RPMI-8226 derivative (ECACC). Originally thought to originate from the peripheral blood of a 57 year old female patient with chronic myelogenous leukemia.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00537.
Characteristics: Produces IgG lambda.
Omics: Deep exome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for EGFR p.Thr751Ile (c.2252C>T) (from parent cell line).
Heterozygous for KRAS p.Gly12Ala (c.35G>C) (CCLE).
Homozygous for TP53 p.Glu285Lys (c.853G>A) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African73.36
Native American0
East Asian, North2.48
East Asian, South0
South Asian0
European, North7.83
European, South16.33
Disease Plasma cell myeloma (NCIt: C3242)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0014 (RPMI-8226)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ECACC; 94072236
Cell line databases/resources CLDB; cl850
CCLE; COLO775_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
DepMap; ACH-001043
Ontologies CLO; CLO_0002559
Biological sample resources BioSample; SAMN10988053
Chemistry resources PharmacoDB; COLO775_217_2019
Other Wikidata; Q54814146
Polymorphism and mutation databases IARC_TP53; 21242
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number14