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Cellosaurus CEM/VM-1 (CVCL_1B35)

[Text version]

Cell line name CEM/VM-1
Synonyms CEM/VM1; CEM-VM1
Accession CVCL_1B35
Resource Identification Initiative To cite this cell line use: CEM/VM-1 (RRID:CVCL_1B35)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:75988; Teniposide (VM-26).
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=2888532
Beck W.T., Cirtain M.C., Danks M.K., Felsted R.L., Safa A.R., Wolverton J.S., Suttle D.P., Trent J.M.
Pharmacological, molecular, and cytogenetic analysis of 'atypical' multidrug-resistant human leukemic cells.
Cancer Res. 47:5455-5460(1987)

PubMed=3469013
Danks M.K., Yalowich J.C., Beck W.T.
Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).
Cancer Res. 47:1297-1301(1987)

Cross-references
Chemistry resources ChEMBL-Cells; CHEMBL3307511
ChEMBL-Targets; CHEMBL614030
Encyclopedic resources Wikidata; Q54809287
Entry history
Entry creation08-Jul-2015
Last entry update23-Jun-2022
Version number14