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Cellosaurus 90-8 (CVCL_1B47)

Cell line name 90-8
Synonyms MPNST 90-8TL; 90-8TL; NF90-8; NF190-8
Accession CVCL_1B47
Resource Identification Initiative To cite this cell line use: 90-8 (RRID:CVCL_1B47)
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; c.96+1G>A (IVS3+1G>A); ClinVar=VCV000860797; Zygosity=Unspecified; Note=Splice donor mutation (PubMed=7522538).
Disease Malignant peripheral nerve sheath tumor (NCIt: C3798)
Neurofibromatosis type 1 (NCIt: C3273)
Malignant peripheral nerve sheath tumor (ORDO: Orphanet_3148)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
Publications

PubMed=1568246; DOI=10.1016/0092-8674(92)90407-4
DeClue J.E., Papageorge A.G., Fletcher J.A., Diehl S.R., Ratner N., Vass W.C., Lowy D.R.
Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis.
Cell 69:265-273(1992)

PubMed=7522538; DOI=10.1002/gcc.2870100405
Legius E., Dierick H., Wu R., Hall B.K., Marynen P., Cassiman J.-J., Glover T.W.
TP53 mutations are frequent in malignant NF1 tumors.
Genes Chromosomes Cancer 10:250-255(1994)

PubMed=10791998; DOI=10.1172/JCI7610
DeClue J.E., Heffelfinger S.C., Benvenuto G., Ling B., Li S.-W., Rui W., Vass W.C., Viskochil D., Ratner N.
Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models.
J. Clin. Invest. 105:1233-1241(2000)

PubMed=16239399; DOI=10.1124/jpet.105.091454
Mattingly R.R., Kraniak J.M., Dilworth J.T., Mathieu P., Bealmear B., Nowak J.E., Benjamins J.A., Tainsky M.A., Reiners J.J. Jr.
The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines.
J. Pharmacol. Exp. Ther. 316:456-465(2006)

PubMed=16510576; DOI=10.1158/0008-5472.CAN-05-3330
Miller S.J., Rangwala F., Williams J., Ackerman P., Kong S., Jegga A.G., Kaiser S., Aronow B.J., Frahm S., Kluwe L., Mautner V.-F., Upadhyaya M., Muir D.F. IV, Wallace M.R., Hagen J., Quelle D.E., Watson M.A., Perry A., Gutmann D.H., Ratner N.
Large-scale molecular comparison of human Schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Cancer Res. 66:2584-2591(2006)

PubMed=21481793; DOI=10.1016/j.ccr.2011.02.017
Yi C.-L., Troutman S., Fera D., Stemmer-Rachamimov A.O., Avila J.L., Christian N., Persson N.L., Shimono A., Speicher D.W., Marmorstein R., Holmgren L., Kissil J.L.
A tight junction-associated merlin-angiomotin complex mediates merlin's regulation of mitogenic signaling and tumor suppressive functions.
Cancer Cell 19:527-540(2011)

PubMed=28469964
Guo J.-M., Grovola M.R., Xie H., Coggins G.E., Duggan P., Hasan R., Huang J.-L., Lin D.W., Song C., Witek G.M., Berritt S., Schultz D.C., Field J.
Comprehensive pharmacological profiling of neurofibromatosis cell lines.
Am. J. Cancer Res. 7:923-934(2017)

PubMed=32642732; DOI=10.1093/noajnl/vdz049
Pemov A., Li H., Presley W., Wallace M.R., Miller D.T.
Genetics of human malignant peripheral nerve sheath tumors.
Neurooncol. Adv. 2:I50-I61(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_1B47
Encyclopedic resources Wikidata; Q54605631
Experimental variables resources EFO; EFO_0006288
Entry history
Entry creation08-Jul-2015
Last entry update05-Oct-2023
Version number13