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Cellosaurus T47D/TR-2 (CVCL_1D37)

[Text version]

Cell line name T47D/TR-2
Accession CVCL_1D37
Resource Identification Initiative To cite this cell line use: T47D/TR-2 (RRID:CVCL_1D37)
Comments Selected for resistance to: ChEBI; CHEBI:41774; Tamoxifen.
Sequence variations
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Leu194Phe (c.580C>T); ClinVar=VCV000127817; Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D45 (T47D/S2)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=25362855; DOI=10.1038/onc.2014.351
Thrane S., Pedersen A.M., Thomsen M.B.H., Kirkegaard T., Rasmussen B.B., Duun-Henriksen A.K., Laenkholm A.-V., Bak M., Lykkesfeldt A.E., Yde C.W.
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.
Oncogene 34:4199-4210(2015)

Cross-references
Cell line collections CancerTools; 152110
Ximbio; 152110
Encyclopedic resources Wikidata; Q54971578
Entry history
Entry creation08-Jul-2015
Last entry update23-Jun-2022
Version number11