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Cellosaurus T47D/TR-2 (CVCL_1D37)

[Text version]

Cell line name T47D/TR-2
Accession CVCL_1D37
Resource Identification Initiative To cite this cell line use: T47D/TR-2 (RRID:CVCL_1D37)
Comments Selected for resistance to: ChEBI; CHEBI:41774; Tamoxifen.
Sequence variations Heterozygous for PIK3CA p.His1047Arg (c.3140A>G) (ClinVar=VCV000013652) (from parent cell line).
Homozygous for TP53 p.Leu194Phe (c.580C>T) (ClinVar=VCV000127817) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D45 (T47D/S2)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=25362855; DOI=10.1038/onc.2014.351
Thrane S., Pedersen A.M., Thomsen M.B.H., Kirkegaard T., Rasmussen B.B., Duun-Henriksen A.K., Laenkholm A.V., Bak M., Lykkesfeldt A.E., Yde C.W.
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.
Oncogene 34:4199-4210(2015)

Cross-references
Cell line collections Ximbio; 152110
Other Wikidata; Q54971578
Entry history
Entry creation08-Jul-2015
Last entry update29-Oct-2020
Version number9