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Cellosaurus MCF-7/164R-7 (CVCL_1D39)

[Text version]

Cell line name MCF-7/164R-7
Synonyms MCF7/164R-7; 164R-7
Accession CVCL_1D39
Resource Identification Initiative To cite this cell line use: MCF-7/164R-7 (RRID:CVCL_1D39)
Comments Selected for resistance to: ChEBI; CHEBI:31638; Fulvestrant (ICI 182780).
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D47 (MCF-7/S0.5)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=7759159; DOI=10.1002/ijc.2910610417
Lykkesfeldt A.E., Larsen S.S., Briand P.
Human breast cancer cell lines resistant to pure anti-estrogens are sensitive to tamoxifen treatment.
Int. J. Cancer 61:529-534(1995)

PubMed=25362855; DOI=10.1038/onc.2014.351
Thrane S., Pedersen A.M., Thomsen M.B.H., Kirkegaard T., Rasmussen B.B., Duun-Henriksen A.K., Laenkholm A.V., Bak M., Lykkesfeldt A.E., Yde C.W.
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.
Oncogene 34:4199-4210(2015)

Cross-references
Cell line collections Ximbio; 152103
Other Wikidata; Q54904341
Entry history
Entry creation08-Jul-2015
Last entry updated25-Feb-2019
Version number8