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Cellosaurus MCF-7/182R-7 (CVCL_1D41)

[Text version]

Cell line name MCF-7/182R-7
Synonyms MCF7/182R-7; 182R-7
Accession CVCL_1D41
Resource Identification Initiative To cite this cell line use: MCF-7/182R-7 (RRID:CVCL_1D41)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:31638; Fulvestrant (ICI 182780).
Sequence variations Gene deletion; CDKN2A; Zygosity=Homozygous (from parent cell line).
Heterozygous for GATA3 p.Asp336Glyfs*17 (c.1006dupG) (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D47 (MCF-7/S0.5)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=7759159; DOI=10.1002/ijc.2910610417
Lykkesfeldt A.E., Larsen S.S., Briand P.
Human breast cancer cell lines resistant to pure anti-estrogens are sensitive to tamoxifen treatment.
Int. J. Cancer 61:529-534(1995)

PubMed=16172194; DOI=10.1677/erc.1.00946
Frogne T., Jepsen J.S., Larsen S.S., Fog C.K., Brockdorff B.L., Lykkesfeldt A.E.
Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth.
Endocr. Relat. Cancer 12:599-614(2005)

Cross-references
Cell line collections Ximbio; 152106
Other Wikidata; Q54904344
Entry history
Entry creation08-Jul-2015
Last entry update12-Jan-2021
Version number11