AC   CVCL_1D42
SY   MCF7/TAMR-4; TAMR-4; TamR-4; TamR4
DR   ECACC; 16022528
DR   Wikidata; Q54904382
DR   Ximbio; 152088
RX   PubMed=16172194;
RX   PubMed=25362855;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:41774; Tamoxifen.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from metastatic site: Pleural effusion.
ST   Source(s): ECACC
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 11
ST   D16S539: 11,12
ST   D18S51: 14
ST   D21S11: 30
ST   D3S1358: 16
ST   D5S818: 11,12
ST   D7S820: 8,9
ST   D8S1179: 10,14
ST   FGA: 23,25
ST   Penta D: 12
ST   Penta E: 7,12
ST   TH01: 6
ST   TPOX: 9,12
ST   vWA: 14,15
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_1D47 ! MCF-7/S0.5
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 20-05-21; Version: 12
RX   PubMed=16172194; DOI=10.1677/erc.1.00946;
RA   Frogne T., Jepsen J.S., Larsen S.S., Fog C.K., Brockdorff B.L.,
RA   Lykkesfeldt A.E.;
RT   "Antiestrogen-resistant human breast cancer cells require activated
RT   protein kinase B/Akt for growth.";
RL   Endocr. Relat. Cancer 12:599-614(2005).
RX   PubMed=25362855; DOI=10.1038/onc.2014.351;
RA   Thrane S., Pedersen A.M., Thomsen M.B.H., Kirkegaard T.,
RA   Rasmussen B.B., Duun-Henriksen A.K., Laenkholm A.-V., Bak M.,
RA   Lykkesfeldt A.E., Yde C.W.;
RT   "A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as
RT   novel treatment targets in antiestrogen-resistant breast cancer
RT   cells.";
RL   Oncogene 34:4199-4210(2015).