Cellosaurus

Cellosaurus MCF-7/TAMR-8 (CVCL_1D44)

Cross-references
Cell line name	MCF-7/TAMR-8
Synonyms	MCF7/TAMR-8; TAMR-8; TamR8
Accession	CVCL_1D44
Resource Identification Initiative	To cite this cell line use: MCF-7/TAMR-8 (RRID:CVCL_1D44)
Comments	Selected for resistance to: ChEBI; CHEBI:41774; Tamoxifen.
Sequence variations	Homozygous for CDKN2A deletion (from parent cell line). Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (from parent cell line).
Disease	Invasive ductal carcinoma, not otherwise specified (NCIt: C4194) Derived from metastatic site: Pleural effusion.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_1D47 (MCF-7/S0.5)
Sex of cell	Female
Age at sampling	69Y
Category	Cancer cell line
Publications	PubMed=16172194; DOI=10.1677/erc.1.00946 Frogne T., Jepsen J.S., Larsen S.S., Fog C.K., Brockdorff B.L., Lykkesfeldt A.E. Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth. Endocr. Relat. Cancer 12:599-614(2005) PubMed=25362855; DOI=10.1038/onc.2014.351 Thrane S., Pedersen A.M., Thomsen M.B.H., Kirkegaard T., Rasmussen B.B., Duun-Henriksen A.K., Laenkholm A.V., Bak M., Lykkesfeldt A.E., Yde C.W. A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells. Oncogene 34:4199-4210(2015)
Cell line collections	ECACC; 16022510 Ximbio; 152086
Other	Wikidata; Q54904384
Entry history
Entry creation	08-Jul-2015
Last entry updated	25-Feb-2019
Version number	8

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