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Cellosaurus MCF-7/TAMR-8 (CVCL_1D44)

[Text version]

Cell line name MCF-7/TAMR-8
Synonyms MCF7/TAMR-8; TAMR-8; TamR8
Accession CVCL_1D44
Resource Identification Initiative To cite this cell line use: MCF-7/TAMR-8 (RRID:CVCL_1D44)
Comments Selected for resistance to: ChEBI; CHEBI:41774; Tamoxifen.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D47 (MCF-7/S0.5)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

PubMed=16172194; DOI=10.1677/erc.1.00946
Frogne T., Jepsen J.S., Larsen S.S., Fog C.K., Brockdorff B.L., Lykkesfeldt A.E.
Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth.
Endocr. Relat. Cancer 12:599-614(2005)

PubMed=25362855; DOI=10.1038/onc.2014.351
Thrane S., Pedersen A.M., Thomsen M.B.H., Kirkegaard T., Rasmussen B.B., Duun-Henriksen A.K., Laenkholm A.V., Bak M., Lykkesfeldt A.E., Yde C.W.
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.
Oncogene 34:4199-4210(2015)

Cell line collections ECACC; 16022510
Ximbio; 152086
Other Wikidata; Q54904384
Entry history
Entry creation08-Jul-2015
Last entry updated25-Feb-2019
Version number8