Home  |  Contact

Cellosaurus 2C4 [Human fibrosarcoma] (CVCL_1D50)

[Text version]
Cell line name 2C4 [Human fibrosarcoma]
Accession CVCL_1D50
Resource Identification Initiative To cite this cell line use: 2C4 [Human fibrosarcoma] (RRID:CVCL_1D50)
Comments Population: Caucasian.
Characteristics: Expression of CD2 is under the control of the IFITM1 promoter inducible by interferon gamma.
Transfected with: HGNC; 1639; CD2.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0317 (HT-1080)
Children:
CVCL_C0D3 (2C4 gamma1A)CVCL_C0D4 (2C4 gamma2A)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=7901766; DOI=10.1038/366166a0
Watling D., Guschin D.Y., Muller M., Silvennoinen O., Witthuhn B.A., Quelle F.W., Rogers N.C., Schindler C., Stark G.R., Ihle J.N., Kerr I.M.
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.
Nature 366:166-170(1993)

PubMed=9001223; DOI=10.1128/mcb.17.2.695
Kohlhuber F., Rogers N.C., Watling D., Feng J., Guschin D.Y., Briscoe J., Witthuhn B.A., Kotenko S.V., Pestka S., Stark G.R., Ihle J.N., Kerr I.M.
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.
Mol. Cell. Biol. 17:695-706(1997)

Cross-references
Cell line collections (Providers) CancerTools; 153235
Ximbio; 154235
Cell line databases/resources cancercelllines; CVCL_1D50
Encyclopedic resources Wikidata; Q54584423
Entry history
Entry creation08-Jul-2015
Last entry update05-Oct-2023
Version number16