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Cellosaurus MDA-MB-231-luc-D3H1 (CVCL_1D88)

[Text version]

Cell line name MDA-MB-231-luc-D3H1
Synonyms D3H1
Accession CVCL_1D88
Resource Identification Initiative To cite this cell line use: MDA-MB-231-luc-D3H1 (RRID:CVCL_1D88)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Transfected with: UniProtKB; P08659; Firefly luciferase.
Sequence variations Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Children:
CVCL_D257 (MDA-MB-231-luc-D3H2LN)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=15987449; DOI=10.1186/bcr1026
Jenkins D.E., Hornig Y.S., Oei Y.A., Dusich J.M., Purchio T.
Bioluminescent human breast cancer cell lines that permit rapid and sensitive in vivo detection of mammary tumors and multiple metastases in immune deficient mice.
Breast Cancer Res. 7:R444-R454(2005)

Cross-references
Cell line collections PerkinElmer; 119261 - Discontinued
Other Wikidata; Q54904598
Entry history
Entry creation08-Jul-2015
Last entry update20-May-2021
Version number13