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Cellosaurus MDA-MB-231-tdTomato (CVCL_1D91)

[Text version]

Cell line name MDA-MB-231-tdTomato
Accession CVCL_1D91
Resource Identification Initiative To cite this cell line use: MDA-MB-231-tdTomato (RRID:CVCL_1D91)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Transfected with: tdTomato; a bright red fluorescent protein derived from drFP583 (DsRed).
Sequence variations Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 1097; BRAF; Simple; p.Gly464Val (c.1391G>T); ClinVar=VCV000040364; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg280Lys (c.839G>A); ClinVar=VCV000376657; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Cross-references
Cell line collections PerkinElmer; 125737 - Discontinued
Other Wikidata; Q54904608
Entry history
Entry creation08-Jul-2015
Last entry update20-May-2021
Version number13