Cell line name |
JLTRG |
Synonyms |
JLTR-RS; Jurkat LTR-GFP |
Accession |
CVCL_1E01 |
Resource Identification Initiative |
To cite this cell line use: JLTRG (RRID:CVCL_1E01) |
Comments |
Population: Caucasian. Virology: Reporter cell line that expresses eGFP as a direct and quantitative marker of HIV-1 infection. The expression of eGFP is under the control of a HIV-1 LTR. Doubling time: 24-48 hours (HIVReagentProgram=ARP-11587). Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP). Transfected with: UniProtKB; P00552; Transposon Tn5 neo. Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0065 (Jurkat) Children:
|
Sex of cell |
Male |
Age at sampling |
14Y |
Category |
Cancer cell line |
Publications | PubMed=15105117; DOI=10.1128/AAC.48.5.1652-1663.2004 Kutsch O., Levy D.N., Bates P.J., Decker J., Kosloff B.R., Shaw G.M., Priebe W., Benveniste E.N. Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription. Antimicrob. Agents Chemother. 48:1652-1663(2004) PubMed=16454046; DOI=10.2144/000112072 Ochsenbauer-Jambor C., Jones J., Heil M., Zammit K.P., Kutsch O. T-cell line for HIV drug screening using EGFP as a quantitative marker of HIV-1 replication. BioTechniques 40:91-100(2006) |
Cross-references |
Cell line collections (Providers) |
HIVReagentProgram; ARP-11587
|
Cell line databases/resources |
cancercelllines; CVCL_1E01
|
Encyclopedic resources |
Wikidata; Q54898984
|
Entry history |
Entry creation | 08-Jul-2015 |
Last entry update | 05-Oct-2023 |
Version number | 19 |
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