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Cellosaurus BC7 (CVCL_1E03)

[Text version]
Cell line name BC7
Accession CVCL_1E03
Resource Identification Initiative To cite this cell line use: BC7 (RRID:CVCL_1E03)
Comments Population: Caucasian.
Characteristics: CD4 negative.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); ClinVar=VCV001057635; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T lymphoblastic lymphoma (NCIt: C7210)
T-cell non-Hodgkin lymphoma (ORDO: Orphanet_171918)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1714 (SUP-T1)
Children:
CVCL_ZX81 (BC7/CCR5)
Sex of cell Male
Age at sampling 8Y
Category Cancer cell line
Publications

PubMed=8929542; DOI=10.1016/S0092-8674(00)81393-8
Endres M.J., Clapham P.R., Marsh M., Ahuja M., Turner J.D., McKnight A., Thomas J.F., Stoebenau-Haggarty B., Choe S., Vance P.J., Wells T.N.C., Power C.A., Sutterwala S.S., Doms R.W., Landau N.R., Hoxie J.A.
CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.
Cell 87:745-756(1996)

PubMed=11264379; DOI=10.1128/JVI.75.8.3903-3915.2001
Means R.E., Matthews T., Hoxie J.A., Malim M.H., Kodama T., Desrosiers R.C.
Ability of the V3 loop of simian immunodeficiency virus to serve as a target for antibody-mediated neutralization: correlation of neutralization sensitivity, growth in macrophages, and decreased dependence on CD4.
J. Virol. 75:3903-3915(2001)

Cross-references
Cell line collections (Providers) HIVReagentProgram; ARP-11434
Cell line databases/resources cancercelllines; CVCL_1E03
Encyclopedic resources Wikidata; Q54795315
Entry history
Entry creation08-Jul-2015
Last entry update05-Oct-2023
Version number14