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Cellosaurus HROC69 (CVCL_1G06)

[Text version]
Cell line name HROC69
Synonyms HROC69P
Accession CVCL_1G06
Resource Identification Initiative To cite this cell line use: HROC69 (RRID:CVCL_1G06)
Comments From: Linnebacher M.; University of Rostock; Rostock; Germany.
Population: Caucasian.
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Arg1450Ter (c.4348C>T); ClinVar=VCV000194585; Zygosity=Unspecified (PubMed=27087592).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Glu7Ter (c.19G>T); ClinVar=VCV000493079; Zygosity=Unspecified (PubMed=27087592).
  • Mutation; HGNC; 6769; SMAD3; Simple; p.Ala382Val (c.1145C>T); dbSNP=rs779602560; Zygosity=Unspecified (PubMed=27087592).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (PubMed=27087592).
HLA typing Source: Direct_author_submission
Class I
HLA-AA*26:01,33:01
HLA-BB*18:01,52:01
HLA-CC*12:02,12:03
Class II
HLA-DQDQB1*03:01,06:01
HLA-DRDRB1*11:04,15:02
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_YD53 ! B-LCL-HROC69
CVCL_1G07 ! HROC69 T0 M2
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): CLS; PubMed=25926053; PubMed=27087592

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81812,13
D7S82010,12
D13S31711,12,13 (PubMed=25926053)
12 (CLS; PubMed=27087592)
D16S53911,12 (CLS; PubMed=27087592)
12,13 (PubMed=25926053)
D21S1129,33.2
TH017,9.3 (CLS; PubMed=25926053)
7,10 (PubMed=27087592)
TPOX8,12
vWA17,19 (CLS; PubMed=25926053)
17,20 (PubMed=27087592)

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Publications

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=27087592; DOI=10.1038/srep24671
Kuehn F., Mullins C.S., Krohn M., Harnack C., Ramer R., Kramer O.H., Klar E., Huhns M., Linnebacher M.
Establishment and characterization of HROC69 -- a Crohn s related colonic carcinoma cell line and its matched patient-derived xenograft.
Sci. Rep. 6:24671-24671(2016)

PubMed=31601052; DOI=10.3390/cancers11101520
Mullins C.S., Micheel B., Matschos S., Leuchter M., Burtin F., Krohn M., Huhns M., Klar E., Prall F., Linnebacher M.
Integrated biobanking and tumor model establishment of human colorectal carcinoma provides excellent tools for preclinical research.
Cancers (Basel) 11:1520.1-1520.18(2019)

Cross-references
Cell line collections (Providers) CLS; 300828
Cell line databases/resources cancercelllines; CVCL_1G06
Encyclopedic resources Wikidata; Q54895301
Gene expression databases GEO; GSM1448080
Polymorphism and mutation databases Cosmic; 2795028
Entry history
Entry creation08-Jul-2015
Last entry update05-Oct-2023
Version number19