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Cellosaurus HROC69 T0 M2 (CVCL_1G07)

[Text version]
Cell line name HROC69 T0 M2
Synonyms HROC69X
Accession CVCL_1G07
Resource Identification Initiative To cite this cell line use: HROC69 T0 M2 (RRID:CVCL_1G07)
Comments From: Linnebacher M.; University of Rostock; Rostock; Germany.
Population: Caucasian.
Characteristics: Established from a patient-derived xenograft established in female NMRI nu/nu mice.
Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Arg1450Ter (c.4348C>T); ClinVar=VCV000194585; Zygosity=Unspecified (PubMed=27087592).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Glu7Ter (c.19G>T); ClinVar=VCV000493079; Zygosity=Unspecified (PubMed=27087592).
  • Mutation; HGNC; 6769; SMAD3; Simple; p.Ala382Val (c.1145C>T); dbSNP=rs779602560; Zygosity=Unspecified (PubMed=27087592).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (PubMed=27087592).
HLA typing Source: Direct_author_submission
Class I
HLA-AA*26:01,33:01
HLA-BB*18:01,52:01
HLA-CC*12:02,12:03
Class II
HLA-DQDQB1*03:01,06:01
HLA-DRDRB1*11:04,15:02
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_YD53 ! B-LCL-HROC69
CVCL_1G06 ! HROC69
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): CLS; PubMed=27087592

Markers:
AmelogeninX,Y
CSF1PO10,11
D5S81812,13
D7S82010,12
D13S31712
D16S53912,13
TH017,10
TPOX8,12
vWA17

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Publications

PubMed=27087592; DOI=10.1038/srep24671
Kuehn F., Mullins C.S., Krohn M., Harnack C., Ramer R., Kramer O.H., Klar E., Huhns M., Linnebacher M.
Establishment and characterization of HROC69 -- a Crohn s related colonic carcinoma cell line and its matched patient-derived xenograft.
Sci. Rep. 6:24671-24671(2016)

PubMed=31601052; DOI=10.3390/cancers11101520
Mullins C.S., Micheel B., Matschos S., Leuchter M., Burtin F., Krohn M., Huhns M., Klar E., Prall F., Linnebacher M.
Integrated biobanking and tumor model establishment of human colorectal carcinoma provides excellent tools for preclinical research.
Cancers (Basel) 11:1520.1-1520.18(2019)

Cross-references
Cell line collections (Providers) CLS; 300829
Cell line databases/resources cancercelllines; CVCL_1G07
Encyclopedic resources Wikidata; Q54895302
Polymorphism and mutation databases Cosmic; 2795027
Entry history
Entry creation08-Jul-2015
Last entry update05-Oct-2023
Version number17