ID   AtT-20ins
AC   CVCL_1G40
SY   AtT-20 ins
DR   Wikidata; Q54751303
RX   PubMed=1309953;
RX   PubMed=8325893;
RX   PubMed=8433987;
RX   PubMed=8697299;
CC   Transfected with: HGNC; 6081; INS.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Pituitary gland; UBERON=UBERON_0000007.
CC   Breed/subspecies: LAF1.
DI   NCIt; C24037; Mouse pituitary gland neoplasms
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_2300 ! AtT-20
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 29-06-23; Version: 7
//
RX   PubMed=1309953; DOI=10.1073/pnas.89.2.688;
RA   Hughes S.D., Johnson J.H., Quaade C., Newgard C.B.;
RT   "Engineering of glucose-stimulated insulin secretion and biosynthesis
RT   in non-islet cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 89:688-692(1992).
//
RX   PubMed=8325893; DOI=10.1016/S0021-9258(18)82457-7;
RA   Hughes S.D., Quaade C., Johnson J.H., Ferber S., Newgard C.B.;
RT   "Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers
RT   glucose-stimulated insulin secretion. Relationship to glucose
RT   metabolism.";
RL   J. Biol. Chem. 268:15205-15212(1993).
//
RX   PubMed=8433987; DOI=10.1073/pnas.90.4.1281;
RA   Inman L.R., McAllister C.T., Chen L., Hughes S.D., Newgard C.B.,
RA   Kettman J.R., Unger R.H., Johnson J.H.;
RT   "Autoantibodies to the GLUT-2 glucose transporter of beta cells in
RT   insulin-dependent diabetes mellitus of recent onset.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:1281-1284(1993).
//
RX   PubMed=8697299;
RA   Poitout V., Olson L.K., Robertson R.P.;
RT   "Insulin-secreting cell lines: classification, characteristics and
RT   potential applications.";
RL   Diabetes Metab. 22:7-14(1996).
//