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Cellosaurus NP-2/CD4 (CVCL_1R18)

[Text version]
Cell line name NP-2/CD4
Synonyms NP2/CD4; NP2-CD4; NP-2/CD4/EcoVR
Accession CVCL_1R18
Resource Identification Initiative To cite this cell line use: NP-2/CD4 (RRID:CVCL_1R18)
Comments Population: Japanese.
Transfected with: HGNC; 1678; CD4.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Brain, left frontal lobe; UBERON=UBERON_0002811.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Met237Ile (c.711G>T); ClinVar=VCV000634770; Zygosity=Unspecified (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1R15 (NP-2)
Children:
CVCL_1R25 (NP-2/CD4/APJ)CVCL_1R26 (NP-2/CD4/CCR3)CVCL_1R27 (NP-2/CD4/CCR5)
CVCL_A6UR (NP-2/CD4/CCR6)CVCL_1R28 (NP-2/CD4/CCR8)CVCL_1R29 (NP-2/CD4/CXCR4)
CVCL_A6US (NP-2/CD4/FPRL1)CVCL_1R30 (NP-2/CD4/GPR1)CVCL_A7BP (NP-2/CD4/RDC1)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=10329384; DOI=10.1006/bbrc.1999.0633
Soda Y., Shimizu N., Jinno A., Liu H.-Y., Kanbe K., Kitamura T., Hoshino H.
Establishment of a new system for determination of coreceptor usages of HIV based on the human glioma NP-2 cell line.
Biochem. Biophys. Res. Commun. 258:313-321(1999)

PubMed=11112502; DOI=10.1006/viro.2000.0623
Liu H.-Y., Soda Y., Shimizu N., Haraguchi Y., Jinno A., Takeuchi Y., Hoshino H.
CD4-dependent and CD4-independent utilization of coreceptors by human immunodeficiency viruses type 2 and simian immunodeficiency viruses.
Virology 278:276-288(2000)

PubMed=18577234; DOI=10.1186/1742-4690-5-52
Shimizu N., Tanaka A., Mori T., Ohtsuki T., Hoque A., Jinno-Oue A., Apichartpiyakul C., Kusagawa S., Takebe Y., Hoshino H.
A formylpeptide receptor, FPRL1, acts as an efficient coreceptor for primary isolates of human immunodeficiency virus.
Retrovirology 5:52.1-52.14(2008)

DOI=10.2974/kmj.62.1
Hoshino H.
The NP-2 cell system for analyses of the coreceptor usage of human and simian immunodeficiency viruses.
Kitakanto Med. J. 62:1-14(2012)

Cross-references
Cell line collections (Providers) RCB; RCB5305
Cell line databases/resources cancercelllines; CVCL_1R18
Encyclopedic resources Wikidata; Q54930945
Entry history
Entry creation08-Jul-2015
Last entry update05-Oct-2023
Version number10