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Cellosaurus NP-2/CD4/CCR5 (CVCL_1R27)

[Text version]
Cell line name NP-2/CD4/CCR5
Synonyms NP2/CD4/CCR5; NP2-CD4/CCR5; NP2/CD4/R5; NP-2/CD4/EcoVR/CCR5
Accession CVCL_1R27
Resource Identification Initiative To cite this cell line use: NP-2/CD4/CCR5 (RRID:CVCL_1R27)
Comments Population: Japanese.
Transfected with: HGNC; 1606; CCR5.
Transfected with: HGNC; 1678; CD4.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR).
Derived from site: In situ; Brain, left frontal lobe; UBERON=UBERON_0002811.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Met237Ile (c.711G>T); ClinVar=VCV000634770; Zygosity=Unspecified (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1R18 (NP-2/CD4)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=10623723; DOI=10.1128/jvi.74.2.619-626.2000
Shimizu N., Soda Y., Kanbe K., Liu H.-Y., Mukai R., Kitamura T., Hoshino H.
A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses.
J. Virol. 74:619-626(2000)

PubMed=11112502; DOI=10.1006/viro.2000.0623
Liu H.-Y., Soda Y., Shimizu N., Haraguchi Y., Jinno A., Takeuchi Y., Hoshino H.
CD4-dependent and CD4-independent utilization of coreceptors by human immunodeficiency viruses type 2 and simian immunodeficiency viruses.
Virology 278:276-288(2000)

PubMed=18577234; DOI=10.1186/1742-4690-5-52
Shimizu N., Tanaka A., Mori T., Ohtsuki T., Hoque A., Jinno-Oue A., Apichartpiyakul C., Kusagawa S., Takebe Y., Hoshino H.
A formylpeptide receptor, FPRL1, acts as an efficient coreceptor for primary isolates of human immunodeficiency virus.
Retrovirology 5:52.1-52.14(2008)

DOI=10.2974/kmj.62.1
Hoshino H.
The NP-2 cell system for analyses of the coreceptor usage of human and simian immunodeficiency viruses.
Kitakanto Med. J. 62:1-14(2012)

PubMed=22178016; DOI=10.1016/j.micinf.2011.11.005
Hoque S.A., Ohtsuki T., Tatsumi M., Shimizu N., Islam S., Jinno-Oue A., Hoshino H.
Lack of the trans-receptor mechanism of HIV-1 infection: CD4- and coreceptor-independent incorporation of HIV-1-resistant cells into syncytia induced by HIV-1.
Microbes Infect. 14:357-368(2012)

Cross-references
Cell line collections (Providers) RCB; RCB5307
Cell line databases/resources cancercelllines; CVCL_1R27
Encyclopedic resources Wikidata; Q54930951
Entry history
Entry creation08-Jul-2015
Last entry update05-Oct-2023
Version number10