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Cellosaurus C2 [Dog mastocytoma] (CVCL_1R44)

[Text version]
Cell line name C2 [Dog mastocytoma]
Synonyms C2-S
Accession CVCL_1R44
Resource Identification Initiative To cite this cell line use: C2 [Dog mastocytoma] (RRID:CVCL_1R44)
Comments Part of: FACC canine tumor cell line panel.
Doubling time: 49.3 +- 12.5 hours (PubMed=2121170); 21 hours (PubMed=27257868).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Mutation; VGNC; 54284; CCND3; Simple; p.Ala66_Ser67del (c.194_199delGCGCCA); Zygosity=Homozygous (PubMed=31175136).
  • Mutation; VGNC; 42422; KIT; Unexplicit; Tandem duplication of a 48bp sequence; Zygosity=Unspecified (PubMed=10210327).
  • Mutation; VGNC; 47719; TP53; Simple; p.Val162Ala (c.485T>C); Zygosity=Homozygous (PubMed=31175136).
Disease Canine mastocytoma (NCIt: C129077)
Species of origin Canis lupus familiaris (Dog) (Canis familiaris) (NCBI Taxonomy: 9615)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=27197945; PubMed=31175136

Markers:
Dog FHC2010231
Dog FHC2054147,156
Dog FHC2079271
Dog PEZ1107,123
Dog PEZ12270
Dog PEZ20176,184
Dog PEZ3115,119
Dog PEZ5111
Dog PEZ6183,187
Dog PEZ8228,232

Run an STR similarity search on this cell line
Publications

PubMed=2431625; DOI=10.1152/ajpcell.1986.251.6.C935
Lazarus S.C., DeVinney R., McCabe L.J., Finkbeiner W.E., Elias D.J., Gold W.M.
Isolated canine mastocytoma cells: propagation and characterization of two cell lines.
Am. J. Physiol. 251:C935-C944(1986)

PubMed=2121170; DOI=10.1165/ajrcmb/3.5.413
DeVinney R., Gold W.M.
Establishment of two dog mastocytoma cell lines in continuous culture.
Am. J. Respir. Cell Mol. Biol. 3:413-420(1990)

PubMed=1634619; DOI=10.1172/JCI115853
Pennington D.W., Lopez A.R., Thomas P.S., Peck C., Gold W.M.
Dog mastocytoma cells produce transforming growth factor beta 1.
J. Clin. Invest. 90:35-41(1992)

PubMed=10210327; DOI=10.1016/S0301-472X(98)00075-7
London C.A., Galli S.J., Yuuki T., Hu Z.-Q., Helfand S.C., Geissler E.N.
Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit.
Exp. Hematol. 27:689-697(1999)

PubMed=19185923; DOI=10.1016/j.vetimm.2008.12.023
Elders R.C., Baines S.J., Catchpole B.
Susceptibility of the C2 canine mastocytoma cell line to the effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Vet. Immunol. Immunopathol. 130:11-16(2009)

PubMed=25190452; DOI=10.1186/s12917-014-0184-9
Pang L.Y., Argyle S.A., Kamida A., Morrison K.O., Argyle D.J.
The long-acting COX-2 inhibitor mavacoxib (Trocoxil TM) has anti-proliferative and pro-apoptotic effects on canine cancer cell lines and cancer stem cells in vitro.
BMC Vet. Res. 10:184.1-184.11(2014)

PubMed=27257868; DOI=10.1371/journal.pone.0156689
Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.
Intrinsic radiosensitivity and cellular characterization of 27 canine cancer cell lines.
PLoS ONE 11:E0156689-E0156689(2016)

PubMed=26842912; DOI=10.1111/vco.12197
Hartley G., Faulhaber E., Caldwell A., Coy J., Kurihara J., Guth A., Regan D.P., Dow S.W.
Immune regulation of canine tumour and macrophage PD-L1 expression.
Vet. Comp. Oncol. 15:534-549(2017)

PubMed=27197945; DOI=10.1111/vco.12192
Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.
The Flint Animal Cancer Center (FACC) canine tumour cell line panel: a resource for veterinary drug discovery, comparative oncology and translational medicine.
Vet. Comp. Oncol. 15:481-492(2017)

PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346
Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.
Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
Mol. Cancer Ther. 18:1460-1471(2019)

Cross-references
Encyclopedic resources Wikidata; Q54807886
Gene expression databases GEO; GSM1974778
Entry history
Entry creation08-Jul-2015
Last entry update21-Mar-2023
Version number11