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Cellosaurus OS 187 (CVCL_1R50)

[Text version]

Cell line name OS 187
Synonyms OS-187; OS187
Accession CVCL_1R50
Resource Identification Initiative To cite this cell line use: OS 187 (RRID:CVCL_1R50)
Comments Problematic cell line: Contaminated. Shown to be a HCT 15 derivative (PubMed=24046071). Originally thought to originate from an osteosarcoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00485.
Sequence variations Homozygous for APC p.Ile1417fs*2 (c.4248delC) (from parent cell line).
Heterozygous for APC p.Arg2166Ter (c.6496C>T) (from parent cell line).
Heterozygous for B2M c.68-1G>T; splice acceptor mutation and p.Tyr30Ter (c.90C>A) (from parent cell line).
Heterozygous for BRCA2 p.Cys1200fs*1 and p.Asn1784Hisfs*7 (c.5350_5351delAA) (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (from parent cell line).
Heterozygous for TP53 p.Ser241Phe (c.722C>T) (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0292 (HCT 15)
Sex of cell Male
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=15026342; DOI=10.1158/0008-5472.CAN-03-3096
Hughes D.P.M., Thomas D.G., Giordano T.J., Baker L.H., McDonagh K.T.
Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma.
Cancer Res. 64:2047-2053(2004)

PubMed=18483362; DOI=10.1158/1078-0432.CCR-07-1992
Zhang P., Yang Y., Zweidler-McKay P.A., Hughes D.P.M.
Critical role of Notch signaling in osteosarcoma invasion and metastasis.
Clin. Cancer Res. 14:2962-2969(2008)

PubMed=24046071; DOI=10.1158/1078-0432.CCR-13-1914
Zhang P., Yang Y., Zweidler-McKay P.A., Hughes D.P.M.
Retraction: Critical role of Notch signaling in osteosarcoma invasion and metastasis.
Clin. Cancer Res. 19:5256-5257(2013)

Cross-references
Biological sample resources BioSample; SAMN03151646
Other Wikidata; Q54936532
Entry history
Entry creation08-Jul-2015
Last entry updated05-Jul-2019
Version number9