Cellosaurus 222 (CVCL_1T15)

Cell line name 222
Accession CVCL_1T15
Resource Identification Initiative To cite this cell line use: 222 (RRID:CVCL_1T15)
Comments Problematic cell line: Contaminated. Shown to be a PA-1 derivative (PubMed=22710073).
Sequence variations Heterozygous for NRAS p.Gly12Asp (from parent cell line).
Disease Ovarian mixed germ cell tumor (NCIt: C8814)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0479 (PA-1)
Children:
CVCL_1T16 (222TR)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations-v8_0.pdf
Publications

PubMed=2227544; DOI=10.1016/0090-8258(90)90068-V
Bonavida B., Tsuchitani T., Zighelboim J., Berek J.S.
Synergy is documented in vitro with low-dose recombinant tumor necrosis factor, cisplatin, and doxorubicin in ovarian cancer cells.
Gynecol. Oncol. 38:333-339(1990)

PubMed=1918981
Morimoto H., Safrit J.T., Bonavida B.
Synergistic effect of tumor necrosis factor-alpha- and diphtheria toxin-mediated cytotoxicity in sensitive and resistant human ovarian tumor cell lines.
J. Immunol. 147:2609-2616(1991)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

Cross-references
Biological sample resources BioSample; SAMN03151885