Home  |  Contact

Cellosaurus 222 (CVCL_1T15)

[Text version]

Cell line name 222
Accession CVCL_1T15
Resource Identification Initiative To cite this cell line use: 222 (RRID:CVCL_1T15)
Comments Problematic cell line: Contaminated. Shown to be a PA-1 derivative (PubMed=22710073).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00454.
Sequence variations Heterozygous for NRAS p.Gly12Asp (c.35G>A) (from parent cell line).
Heterozygous for TP53 p.Pro316Pro (c.948C>T) (from parent cell line).
Disease Ovarian mixed germ cell tumor (NCIt: C8814)
Mixed germ cell tumor (ORDO: Orphanet_180234)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0479 (PA-1)
CVCL_1T16 (222TR)
Sex of cell Female
Age at sampling 12Y
Category Cancer cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx

PubMed=2227544; DOI=10.1016/0090-8258(90)90068-V
Bonavida B., Tsuchitani T., Zighelboim J., Berek J.S.
Synergy is documented in vitro with low-dose recombinant tumor necrosis factor, cisplatin, and doxorubicin in ovarian cancer cells.
Gynecol. Oncol. 38:333-339(1990)

Morimoto H., Safrit J.T., Bonavida B.
Synergistic effect of tumor necrosis factor-alpha- and diphtheria toxin-mediated cytotoxicity in sensitive and resistant human ovarian tumor cell lines.
J. Immunol. 147:2609-2616(1991)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

Biological sample resources BioSample; SAMN03151885
Other Wikidata; Q54583269
Entry history
Entry creation08-Jul-2015
Last entry updated12-Mar-2020
Version number12