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Cellosaurus COR-L23/R (CVCL_2008)

[Text version]

Cell line name COR-L23/R
Synonyms COR-L23-R; COR-L23R
Accession CVCL_2008
Resource Identification Initiative To cite this cell line use: COR-L23/R (RRID:CVCL_2008)
Comments Doubling time: ~35-40 hours (DSMZ).
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Sequence variations Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
Disease Lung large cell carcinoma (NCIt: C4450)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1139 (COR-L23)
Children:
CVCL_2009 (COR-L23/R23-)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX
CSF1PO11
D2S133823,26
D3S135815
D5S81810,12
D7S8209
D8S117910,13
D13S31710,11
D16S53911,13
D18S5113,16
D19S43314
D21S1131.2
FGA24
Penta D13
Penta E12,20
TH019
TPOX8,11
vWA19

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Publications

PubMed=3011054; DOI=10.1038/bjc.1986.83
Twentyman P.R., Fox N.E., Wright K.A., Bleehen N.M.
Derivation and preliminary characterisation of adriamycin resistant lines of human lung cancer cells.
Br. J. Cancer 53:529-537(1986)

PubMed=7903701; DOI=10.1093/jnci/86.2.110
Barrand M.A., Heppell-Parton A.C., Wright K.A., Rabbitts P.H., Twentyman P.R.
A 190-kilodalton protein overexpressed in non-P-glycoprotein-containing multidrug-resistant cells and its relationship to the MRP gene.
J. Natl. Cancer Inst. 86:110-117(1994)

PubMed=12606785; DOI=10.1124/mol.63.3.742
Briz O., Macias R.I.R., Vallejo M., Silva A., Serrano M.A., Marin J.J.G.
Usefulness of liposomes loaded with cytostatic bile acid derivatives to circumvent chemotherapy resistance of enterohepatic tumors.
Mol. Pharmacol. 63:742-750(2003)

Cross-references
Cell line collections DSMZ; ACC-883
ECACC; 96042339
Cell line databases/resources CLDB; cl5055
Cell_Model_Passport; SIDM01204
Ontologies CLO; CLO_0002587
Other Wikidata; Q54814273
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number15