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Cellosaurus COV434 (CVCL_2010)

[Text version]

Cell line name COV434
Synonyms COV-434; COV 434
Accession CVCL_2010
Resource Identification Initiative To cite this cell line use: COV434 (RRID:CVCL_2010)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Characteristics: Because it conserved a number of properties of normal human granulosa cells, it is used in the investigation of such cell type.
Doubling time: 24 hours (PubMed=25984343).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.5
Native American0.68
East Asian, North0.76
East Asian, South0
South Asian0
European, North60.55
European, South36.51
Disease Ovarian granulosa cell tumor (NCIt: C6261)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ECACC; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,11
D3S135815,19
D5S81810,11
D7S8208
D8S117913,14
D13S3178,12
D16S5399,12
D18S5110,15
D21S1128
FGA24,25
Penta D10,12
Penta E12
TH019.3
TPOX9,11
vWA16,18

Run an STR similarity search on this cell line
Web pages https://www.phe-culturecollections.org.uk/media/131227/cov434-cell-line-profile.pdf
Publications

PubMed=8436435; DOI=10.1002/ijc.2910530415
van den Berg-Bakker C.A.M., Hagemeijer A., Franken-Postma E.M., Smit V.T.H.B.M., Kuppen P.J.K., van Ravenswaay Claasen H.H., Cornelisse C.J., Schrier P.I.
Establishment and characterization of 7 ovarian carcinoma cell lines and one granulosa tumor cell line: growth features and cytogenetics.
Int. J. Cancer 53:613-620(1993)

PubMed=9413942; DOI=10.1038/bjc.1997.597
Brouwenstijn N., Slager E.H., Bakker A.B.H., Schreurs M.W.J., van der Spek C.W., Adema G.J., Schrier P.I., Figdor C.G.
Transcription of the gene encoding melanoma-associated antigen gp100 in tissues and cell lines other than those of the melanocytic lineage.
Br. J. Cancer 76:1562-1566(1997)

PubMed=15541573; DOI=10.1016/j.mce.2004.04.018
Havelock J.C., Rainey W.E., Carr B.R.
Ovarian granulosa cell lines.
Mol. Cell. Endocrinol. 228:67-78(2004)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23839242; DOI=10.1038/ncomms3126
Domcke S., Sinha R., Levine D.A., Sander C., Schultz N.
Evaluating cell lines as tumour models by comparison of genomic profiles.
Nat. Commun. 4:2126-2126(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ECACC; 07071909
Cell line databases/resources CCLE; COV434_OVARY
Cell_Model_Passport; SIDM01476
DepMap; ACH-000123
Ontologies EFO; EFO_0006384
Biological sample resources BioSample; SAMN03473273
BioSample; SAMN10987973
Chemistry resources PharmacoDB; COV434_257_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM313704
GEO; GSM886964
GEO; GSM888033
Other Wikidata; Q54814346
Polymorphism and mutation databases Cosmic; 1149408
Cosmic; 1213590
Cosmic; 1429992
Cosmic; 2368539
Cosmic; 2391829
LiGeA; CCLE_469
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number21