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Cellosaurus CX-1 (CVCL_2011)

[Text version]

Cell line name CX-1
Synonyms HT-29/CX-1; CX1
Accession CVCL_2011
Resource Identification Initiative To cite this cell line use: CX-1 (RRID:CVCL_2011)
Comments Part of: MD Anderson Cell Lines Project.
Doubling time: ~24 hours (CLS); ~30 hours (DSMZ).
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for APC p.Glu853Ter (c.2557G>T) and p.Thr1556fs*3 (c.4666_4667insA) (from parent cell line).
Heterozygous for BRAF p.Val600Glu (c.1799T>A) (from parent cell line).
Heterozygous for PIK3CA p.Pro449Thr (c.1345C>A) (from parent cell line).
Homozygous for SMAD4 p.Gln311Ter (c.931C>T) (from parent cell line).
Homozygous for TP53 p.Arg273His (c.818G>A) (PubMed=16418264).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
STR profile Source(s): CLS; DSMZ; PubMed=25877200; PubMed=25926053

Markers:
AmelogeninX
CSF1PO11,12
D3S135815,17
D5S81811,12
D7S82010
D8S117910
D13S31711
D16S53911,12
D18S5113
D21S1129,30
FGA20,22
Penta D11,13
Penta E14,16
TH016,9
TPOX8,9
vWA17,19

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=10737795; DOI=10.1073/pnas.97.7.3352
Rowan A.J., Lamlum H., Ilyas M., Wheeler J., Straub J., Papadopoulou A., Bicknell D.C., Bodmer W.F., Tomlinson I.P.M.
APC mutations in sporadic colorectal tumors: a mutational 'hotspot' and interdependence of the 'two hits'.
Proc. Natl. Acad. Sci. U.S.A. 97:3352-3357(2000)

PubMed=12601555; DOI=10.1007/s100380300014
Ni X.-H., Gu S.-H., Dai J.-L., Cheng H.-P., Guo L.-C., Li L., Ji C.-N., Xie Y., Ying K., Mao Y.-M.
Isolation and characterization of a novel human NM23-H1B gene, a different transcript of NM23-H1.
J. Hum. Genet. 48:96-100(2003)

PubMed=16418264; DOI=10.1073/pnas.0510146103
Liu Y., Bodmer W.F.
Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines.
Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006)

PubMed=20606684; DOI=10.1038/sj.bjc.6605780
Bracht K., Nicholls A.M., Liu Y., Bodmer W.F.
5-fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.
Br. J. Cancer 103:340-346(2010)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., Mariadason J.M., Sieber O.M.
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections CLS; 300159/p496_CX-1
DSMZ; ACC-129
Cell line databases/resources CLDB; cl939
ColonAtlas; CX1
Ontologies BTO; BTO:0002440
CLO; CLO_0002650
EFO; EFO_0006561
Biological sample resources BioSample; SAMN03473136
Chemistry resources ChEMBL-Cells; CHEMBL3307403
ChEMBL-Targets; CHEMBL614566
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM206466
GEO; GSM274761
GEO; GSM274762
GEO; GSM1346835
GEO; GSM1448120
Other Wikidata; Q54817065
Polymorphism and mutation databases Cosmic; 948826
Cosmic; 995389
Cosmic; 1043809
Cosmic; 1374637
Cosmic; 2301971
IARC_TP53; 4561
Entry history
Entry creation04-Apr-2012
Last entry updated25-Feb-2019
Version number21