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Cellosaurus DM-3 (CVCL_2019)

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Cell line name DM-3
Synonyms DM3
Accession CVCL_2019
Resource Identification Initiative To cite this cell line use: DM-3 (RRID:CVCL_2019)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 54 hours (PubMed=23840376); ~50-60 hours (DSMZ).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Sequence variations Mutation; HGNC; 6770; SMAD4; Simple; p.Arg496Leu (c.1487G>T); Zygosity=Homozygous (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North0.58
East Asian, South0.68
South Asian2.16
European, North58.64
European, South37.94
Disease Pleural sarcomatoid mesothelioma (NCIt: C45663)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 62Y
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200

Penta D11,12
Penta E7,12

Run an STR similarity search on this cell line

PubMed=15372243; DOI=10.1007/s00418-004-0701-1
Philippeaux M.-M., Pache J.-C., Dahoun S., Barnet M., Robert J.-H., Mauel J., Spiliopoulos A.
Establishment of permanent cell lines purified from human mesothelioma: morphological aspects, new marker expression and karyotypic analysis.
Histochem. Cell Biol. 122:249-260(2004)

PubMed=23840376; DOI=10.1371/journal.pone.0065903
Szulkin A., Nilsonne G., Mundt F., Wasik A.M., Souri P., Hjerpe A., Dobra K.
Variation in drug sensitivity of malignant mesothelioma cell lines with substantial effects of selenite and bortezomib, highlights need for individualized therapy.
PLoS ONE 8:E65903-E65903(2013)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line collections DSMZ; ACC-595
Cell line databases/resources CCLE; DM3_FIBROBLAST
Cell_Model_Passport; SIDM01505
DepMap; ACH-000742
Biological sample resources BioSample; SAMN03473059
BioSample; SAMN10988453
Chemistry resources PharmacoDB; DM3_295_2019
Gene expression databases ArrayExpress; E-MTAB-2770
Other Wikidata; Q54831188
Polymorphism and mutation databases IARC_TP53; 30031
LiGeA; CCLE_782
Progenetix; CVCL_2019
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number21