Cellosaurus EB1 (CVCL_2027)

Cell line name EB1
Synonyms EB-1; Epstein-Barr-1
Accession CVCL_2027
Secondary accession CVCL_2026
Resource Identification Initiative To cite this cell line use: EB1 (RRID:CVCL_2027)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: MD Anderson Cell Lines Project.
Doubling time: ~30-40 hours (DSMZ).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Epstein-Barr virus-related Burkitt lymphoma (NCIt: C27694)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; CLS; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D13S31711,13
D16S5398,10
D18S5115,16
D21S1130,32.2
D3S135816,17
D5S8188,12
D7S82010,12
D8S117914,15
FGA24,30
Penta D6.4,13 (CLS)
6.3,13 (PubMed=25877200)
Penta E13,17
TH019,9.3 (ATCC; CLS; PubMed=25877200)
9,10 (DSMZ)
TPOX8,9
vWA14,16
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=14090852; DOI=10.1016/S0140-6736(64)92354-2
Epstein M.A., Barr Y.M.
Cultivation in vitro of human lymphoblasts from Burkitt's malignant lymphoma.
Lancet 283:252-253(1964)

PubMed=14293790; DOI=10.1093/jnci/34.2.231
Epstein M.A., Barr Y.M.
Characteristics and mode of growth of tissue culture strain (EB1) of human lymphoblasts from Burkitt's lymphoma.
J. Natl. Cancer Inst. 34:231-240(1965)

PubMed=14293791; DOI=10.1093/jnci/34.2.241
Epstein M.A., Achong B.G.
Fine structural organization of human lymphoblasts of a tissue culture strain (EB1) from Burkitt's lymphoma.
J. Natl. Cancer Inst. 34:241-253(1965)

PubMed=6018567
Miles C.P., O'Neill F.
Chromosome studies of 8 in vitro lines of Burkitt's lymphoma.
Cancer Res. 27:392-402(1967)

PubMed=4894370; DOI=10.1002/1097-0142(196908)24:2<211::AID-CNCR2820240202>3.0.CO;2-3
Southam C.M., Burchenal J.H., Clarkson B.D., Tanzi A., Mackey R., McComb V.
Heterotransplantability of human cell lines derived from leukemia and lymphomas into immunologically tolerant rats.
Cancer 24:211-222(1969)

PubMed=7316467; DOI=10.1111/j.1469-1809.1980.tb00953.x
Povey S., Jeremiah S., Arthur E., Steel M., Klein G.
Differences in genetic stability between human cell lines from patients with and without lymphoreticular malignancy.
Ann. Hum. Genet. 44:119-133(1980)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=8515068
Jain V.K., Judde J.-G., Max E.E., Magrath I.T.
Variable IgH chain enhancer activity in Burkitt's lymphomas suggests an additional, direct mechanism of c-myc deregulation.
J. Immunol. 150:5418-5428(1993)

PubMed=20454443; DOI=10.1155/2010/904767
Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.
J. Biomed. Biotechnol. 2010:904767-904767(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; HTB-60
CLS; 300403/p863_EB1
DSMZ; ACC-80
Cell line databases/resources CLDB; cl1127
CCLE; EB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
IGRhCellID; EB1
LINCS_LDP; LCL-2030
Ontologies BTO; BTO:0003000
CLO; CLO_0002869
CLO; CLO_0002870
EFO; EFO_0002172
Biological sample resources BioSample; SAMN03472402
BioSample; SAMN03473402
Gene expression databases GEO; GSM827341
GEO; GSM886991
GEO; GSM888060
Polymorphism and mutation databases Cosmic; 1086328
Cosmic; 1818341