Cellosaurus EM-3 (CVCL_2033)

Cell line name EM-3
Synonyms EM3
Accession CVCL_2033
Resource Identification Initiative To cite this cell line use: EM-3 (RRID:CVCL_2033)
Comments Doubling time: ~40 hours (DSMZ).
Derived from sampling site: Bone marrow.
Disease Childhood chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C7320)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1196 ! EM-2
Sex of cell Female
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D13S3179,12
D16S53911,12
D5S8188,12
D7S82010
TH019.3
TPOX8,12
vWA14,17
Publications

CLPUB00038
Keating A., Martin P.J., Bernstein I.D., Papayannopoulou T., Raskind W., Singer J.W.
EM-2 and EM-3: two new Ph'+ myeloid cell lines.
(In) Normal and neoplastic hematopoiesis, UCLA symposia on molecular and cellular biology, New Series Vol. 9; Golde D.W., Marks P.M. (eds.); pp.513-520; Alan R. Liss; New York (1983)

PubMed=3856862; DOI=10.1073/pnas.82.6.1810
Konopka J.B., Watanabe S.M., Singer J.W., Collins S.J., Witte O.N.
Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.
Proc. Natl. Acad. Sci. U.S.A. 82:1810-1814(1985)

PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9
Keating A.
Ph positive CML cell lines.
Baillieres Clin. Haematol. 1:1021-1029(1987)

PubMed=10637496
Drexler H.G., Fombonne S., Matsuo Y., Hu Z.-B., Hamaguchi H., Uphoff C.C.
p53 alterations in human leukemia-lymphoma cell lines: in vitro artifact or prerequisite for cell immortalization?
Leukemia 14:198-206(2000)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

Cross-references
Cell line collections DSMZ; ACC-134
Cell line databases/resources CLDB; cl1165
Ontologies BTO; BTO:0005905
CLO; CLO_0002923
Polymorphism and mutation databases Cosmic; 787492
Cosmic; 798662
Cosmic; 994179
Cosmic; 1026571