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Cellosaurus EM-3 (CVCL_2033)

[Text version]

Cell line name EM-3
Synonyms EM3
Accession CVCL_2033
Resource Identification Initiative To cite this cell line use: EM-3 (RRID:CVCL_2033)
Comments Population: Caucasian.
Doubling time: 2 days (CelloPub=CLPUB00038); ~40 hours (DSMZ).
Derived from sampling site: Bone marrow.
Sequence variations Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=10071072; PubMed=15843827).
Disease Childhood chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C7320)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1196 ! EM-2
Sex of cell Female
Age at sampling 5Y
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200


Run an STR similarity search on this cell line

Keating A., Martin P.J., Bernstein I.D., Papayannopoulou T., Raskind W., Singer J.W.
EM-2 and EM-3: two new Ph1+ myeloid cell lines.
(In) Normal and neoplastic hematopoiesis, UCLA symposia on molecular and cellular biology, New Series Vol. 9; Golde D.W., Marks P.M. (eds.); pp.513-520; Alan R. Liss; New York (1983)

PubMed=3856862; DOI=10.1073/pnas.82.6.1810
Konopka J.B., Watanabe S.M., Singer J.W., Collins S.J., Witte O.N.
Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.
Proc. Natl. Acad. Sci. U.S.A. 82:1810-1814(1985)

PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9
Keating A.
Ph positive CML cell lines.
Baillieres Clin. Haematol. 1:1021-1029(1987)

PubMed=10071072; DOI=10.1016/s0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10637496; DOI=10.1038/sj.leu.2401604
Drexler H.G., Fombonne S., Matsuo Y., Hu Z.-B., Hamaguchi H., Uphoff C.C.
p53 alterations in human leukemia-lymphoma cell lines: in vitro artifact or prerequisite for cell immortalization?
Leukemia 14:198-206(2000)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

Cell line collections DSMZ; ACC-134
Cell line databases/resources CLO; CLO_0002923
CLDB; cl1165
Cell_Model_Passport; SIDM01046
Anatomy/cell type resources BTO; BTO:0005905
Encyclopedic resources Wikidata; Q54832265
Polymorphism and mutation databases Cosmic; 787492
Cosmic; 798662
Cosmic; 994179
Cosmic; 1026571
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number18