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Cellosaurus FLO-1 (CVCL_2045)

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Cell line name FLO-1
Synonyms Flo-1; Flo 1; FLO1; FLO
Accession CVCL_2045
Resource Identification Initiative To cite this cell line use: FLO-1 (RRID:CVCL_2045)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Population: Caucasian.
Doubling time: ~40-50 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Genome sequenced.
Omics: Transcriptome analysis.
Derived from sampling site: Esophagus.
Sequence variations Mutation; HGNC; 11998; TP53; Simple; p.Cys277Phe (c.830G>T); ClinVar=VCV000458567; Zygosity=Homozygous (PubMed=20075370; CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0.21
East Asian, North0
East Asian, South0.68
South Asian0.12
European, North71.2
European, South27.15
Disease Barrett adenocarcinoma (NCIt: C7027)
Adenocarcinoma of the esophagus (ORDO: Orphanet_99976)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap; DSMZ; ECACC; PubMed=20075370

Penta D11,12
Penta E5,17

Run an STR similarity search on this cell line

Hughes S.J., Nambu Y., Soldes O.S., Hamstra D., Rehemtulla A., Iannettoni M.D., Orringer M.B., Beer D.G.
Fas/APO-1 (CD95) is not translocated to the cell membrane in esophageal adenocarcinoma.
Cancer Res. 57:5571-5578(1997)

PubMed=10078940; DOI=10.1002/(sici)1098-2744(199902)24:2<128::aid-mc7>3.0.co;2-f
Compton K.R., Orringer M.B., Beer D.G.
Induction of glutathione s-transferase-pi in Barrett's metaplasia and Barrett's adenocarcinoma cell lines.
Mol. Carcinog. 24:128-136(1999)

PubMed=20075370; DOI=10.1093/jnci/djp499
Boonstra J.J., van Marion R., Beer D.G., Lin L., Chaves P., Ribeiro C., Pereira A.D., Roque L., Darnton S.J., Altorki N.K., Schrump D.S., Klimstra D.S., Tang L.H., Eshleman J.R., Alvarez H., Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=23795680; DOI=10.1111/dote.12095
Boonstra J.J., Tilanus H.W., Dinjens W.N.M.
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27594985; DOI=10.12688/f1000research.7033.1
Contino G., Eldridge M.D., Secrier M., Bower L., Elliott R.F., Weaver J., Lynch A.G., Edwards P.A.W., Fitzgerald R.C.
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.
F1000Research 5:1336-1336(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections DSMZ; ACC-698
ECACC; 11012001
Cell line databases/resources CCLE; FLO1_OESOPHAGUS
Cell_Model_Passport; SIDM01041
Cosmic-CLP; 1503361
DepMap; ACH-001500
Ontologies BTO; BTO:0003641
Biological sample resources BioSample; SAMN03473447
Chemistry resources GDSC; 1503361
PharmacoDB; FLO1_367_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1669793
Other Wikidata; Q54834992
Polymorphism and mutation databases Cosmic; 1599339
IARC_TP53; 21628
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number24