Cellosaurus FLO-1 (CVCL_2045)

Cell line name FLO-1
Synonyms Flo-1; FLO
Accession CVCL_2045
Resource Identification Initiative To cite this cell line use: FLO-1 (RRID:CVCL_2045)
Comments Doubling time: ~40-50 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: TP53 p.Cys277Phe (PubMed=20075370).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Genome sequenced.
Disease Esophageal adenocarcinoma (NCIt: C4025)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; ECACC; PubMed=20075370

Markers:
AmelogeninX
CSF1PO11
D13S31711
D16S53912,13
D18S5114,16
D21S1130,32.2
D3S135815
D5S81812,14
D7S8208
D8S117913
FGA21
Penta D11,12
Penta E5,17
TH016
TPOX9,11
vWA16
Publications

PubMed=9407969
Hughes S.J., Nambu Y., Soldes O.S., Hamstra D., Rehemtulla A., Iannettoni M.D., Orringer M.B., Beer D.G.
Fas/APO-1 (CD95) is not translocated to the cell membrane in esophageal adenocarcinoma.
Cancer Res. 57:5571-5578(1997)

PubMed=20075370; DOI=10.1093/jnci/djp499
Boonstra J.J., van Marion R., Beer D.G., Lin L., Chaves P., Ribeiro C., Pereira A.D., Roque L., Darnton S.J., Altorki N.K., Schrump D.S., Klimstra D.S., Tang L.H., Eshleman J.R., Alvarez H., Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=23795680; DOI=10.1111/dote.12095
Boonstra J.J., Tilanus H.W., Dinjens W.N.M.
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

DOI=10.12688/f1000research.7033.1
Contino G., Eldridge M.D., Secrier M., Bower L., Elliott R.F., Weaver J., Lynch A.G., Edwards P.A.W., Fitzgerald R.C.
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.
F1000Research 5:1336-1336(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-698
ECACC; 11012001
Cell line databases/resources Cosmic-CLP; 1503361
GDSC; 1503361
Ontologies BTO; BTO:0003641
Biological sample resources BioSample; SAMN03473447
Gene expression databases GEO; GSM1669793
Polymorphism and mutation databases Cosmic; 1599339