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Cellosaurus FM3 (CVCL_2046)

[Text version]

Cell line name FM3
Synonyms FM-3
Accession CVCL_2046
Resource Identification Initiative To cite this cell line use: FM3 (RRID:CVCL_2046)
Comments Omics: Array-based CGH.
Sequence variations Homozygous for CDKN2A deletion (PubMed=17260012).
HLA typing Source: PubMed=7656272
Class I
HLA-AA*02,03
HLA-BB*07,44

Source: PubMed=15592718
Class I
HLA-AA*02:01
HLA-BB*07:02,44:02
HLA-CC*05:01
Class II
HLA-DPDPB1*04:01
HLA-DQDQB1*06:02,03:01:01
HLA-DRDRB1*04:01:01,15:01
Disease Cutaneous melanoma (NCIt: C3510)
Derived from metastatic site: Right inguinal lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C578 (FM3.13)CVCL_C579 (FM3.26)CVCL_C580 (FM3.29)
CVCL_UI31 (FM3.D)CVCL_UI32 (FM3.P)
Sex of cell Female
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): ECACC; ESTDAB

Markers:
AmelogeninX
CSF1PO11,13
D3S135815,17
D5S81812
D7S82010
D13S31712
D16S53912,13
FGA23
TH016,9.3
TPOX8,11
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=7656272; DOI=10.1007/BF01527402
Kirkin A.F., Petersen T.R., Olsen A.C., Li L., thor Straten P., Zeuthen J.
Generation of human-melanoma-specific T lymphocyte clones defining novel cytolytic targets with panels of newly established melanoma cell lines.
Cancer Immunol. Immunother. 41:71-81(1995)

PubMed=7899823; DOI=10.1111/j.1365-3083.1995.tb03579.x
Olsen A.C., Fossum B., Kirkin A.F., Zeuthen J., Gaudernack G.
A human melanoma cell line, recognized by both HLA class I and class II restricted T cells, is capable of initiating both primary and secondary immune responses.
Scand. J. Immunol. 41:357-364(1995)

PubMed=8665567; DOI=10.1007/s002620050272
Kirkin A.F., thor Straten P., Zeuthen J.
Differential modulation by interferon gamma of the sensitivity of human melanoma cells to cytolytic T cell clones that recognize differentiation or progression antigens.
Cancer Immunol. Immunother. 42:203-212(1996)

PubMed=8968104
Bartkova J., Lukas J., Guldberg P., Alsner J., Kirkin A.F., Zeuthen J., Bartek J.
The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis.
Cancer Res. 56:5475-5483(1996)

PubMed=9288767
Guldberg P., thor Straten P., Birck A., Ahrenkiel V., Kirkin A.F., Zeuthen J.
Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.
Cancer Res. 57:3660-3663(1997)

PubMed=15592718; DOI=10.1007/s00262-004-0561-5
Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello F., Dodi I.A., Lopez Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F.
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Jonsson G., Dahl C., Staaf J., Sandberg T., Bendahl P.-O., Ringner M., Guldberg P., Borg A.
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

Cross-references
Cell line collections ECACC; 13012407
Cell line databases/resources ESTDAB; ESTDAB-007
Gene expression databases GEO; GSM156042
Other Wikidata; Q54835025
Polymorphism and mutation databases Cosmic; 808544
Cosmic; 851400
Cosmic; 1047663