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Cellosaurus GOS-3 (CVCL_2050)

[Text version]

Cell line name GOS-3
Synonyms GOS3
Accession CVCL_2050
Resource Identification Initiative To cite this cell line use: GOS-3 (RRID:CVCL_2050)
Comments Problematic cell line: Contaminated. Shown to be a U-343MGa derivative (PubMed=22570425). Originally thought to originate from the brain of a 55 year old patient with a mixed astro-oligodendroglioma (grade II/III).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00449.
Doubling time: ~50 hours (DSMZ).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.06
Native American0
East Asian, North2.96
East Asian, South0
South Asian0
European, North75.07
European, South20.9
Disease Glioblastoma (NCIt: C3058)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4773 (U-343MGa)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D2S133822,24
D3S135815,17
D5S81812,13
D7S8209,11
D8S117913,14
D13S3179,13
D16S5399,12
D18S5123
D19S43313,14
D21S1131,33.2
FGA19,20
Penta D9,10
Penta E10,12
TH016,9.3
TPOX8,9
vWA17,18

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=9760066; DOI=10.1023/A:1005901423332
Halfter H., Kremerskothen J., Weber J., Hacker-Klom U., Barnekow A., Ringelstein E.B., Stogbauer F.
Growth inhibition of newly established human glioma cell lines by leukemia inhibitory factor.
J. Neurooncol. 39:1-18(1998)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22570425; DOI=10.1093/neuonc/nos072
Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K., Hamou M.-F., Delorenzi M., Hegi M.E.
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections DSMZ; ACC-408
Cell line databases/resources CCLE; GOS3_CENTRAL_NERVOUS_SYSTEM
Cell_Model_Passport; SIDM01635
DepMap; ACH-000027
LINCS_LDP; LCL-1406
Ontologies CLO; CLO_0003550
Biological sample resources BioSample; SAMN03151979
BioSample; SAMN03470943
BioSample; SAMN10987798
Chemistry resources PharmacoDB; GOS3_408_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887026
GEO; GSM888096
Other Wikidata; Q54871613
Polymorphism and mutation databases LiGeA; CCLE_213
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number20