Cellosaurus HNT-34 (CVCL_2071)

Cell line name HNT-34
Synonyms HNT34
Accession CVCL_2071
Resource Identification Initiative To cite this cell line use: HNT-34 (RRID:CVCL_2071)
Comments Doubling time: 34 hours (PubMed=25984343); ~40 hours (DSMZ).
Omics: Deep RNAseq analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Adult acute myeloid leukemia (NCIt: C9154)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200; RCB

Markers:
AmelogeninX
CSF1PO11,13
D13S31710,11
D16S5399,12
D18S5113,16
D21S1128,32.2
D3S135816
D5S81813
D7S8208,11
D8S117913,14
FGA20,26
Penta D10
Penta E11,14
TH016,9
TPOX11
vWA14
Publications

PubMed=9266939; DOI=10.1046/j.1365-2141.1997.2143029.x
Hamaguchi H., Suzukawa K., Nagata K., Yamamoto K., Yagasaki F., Morishita K.
Establishment of a novel human myeloid leukaemia cell line (HNT-34) with t(3;3)(q21;q26), t(9;22)(q34;q11) and the expression of EVI1 gene, P210 and P190 BCR/ABL chimaeric transcripts from a patient with AML after MDS with 3q21q26 syndrome.
Br. J. Haematol. 98:399-407(1997)

PubMed=10637496
Drexler H.G., Fombonne S., Matsuo Y., Hu Z.-B., Hamaguchi H., Uphoff C.C.
p53 alterations in human leukemia-lymphoma cell lines: in vitro artifact or prerequisite for cell immortalization?
Leukemia 14:198-206(2000)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Cross-references
Cell line collections DSMZ; ACC-600
RCB; RCB1296
Ontologies CLO; CLO_0050982
EFO; EFO_0006583
Biological sample resources BioSample; SAMN01821631
BioSample; SAMN03472915
Gene expression databases GEO; GSM1446757
Polymorphism and mutation databases Cosmic; 787435
Cosmic; 975253
Cosmic; 1012069
Cosmic; 1281316
Cosmic; 2306209
Cosmic; 2378086