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Cellosaurus IGR-37 (CVCL_2075)

[Text version]

Cell line name IGR-37
Synonyms IgR-37; IGR 37; IGR37; MM1
Accession CVCL_2075
Resource Identification Initiative To cite this cell line use: IGR-37 (RRID:CVCL_2075)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~48-72 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.28
Native American0.29
East Asian, North1.79
East Asian, South0
South Asian0
European, North61.87
European, South34.77
Disease Melanoma (NCIt: C3224)
Derived from metastatic site: Groin lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2076 ! IGR-39
Sex of cell Male
Age at sampling 26Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135817,18
D5S81811,12
D7S82010,11
D8S117914,15
D13S31712
D16S53911
D18S5114,15
D21S1131.2,32.2
FGA22
Penta D9
Penta E12,16
TH019
TPOX8,11
vWA17,21

Run an STR similarity search on this cell line
Publications

PubMed=405430; DOI=10.1111/1523-1747.ep12496554
Foa C., Aubert C.
Cellular localization of tyrosinase in human malignant melanoma cell lines.
J. Invest. Dermatol. 68:369-378(1977)

PubMed=6929009; DOI=10.1093/jnci/64.5.1029
Aubert C., Rouge F., Galindo J.R.
Tumorigenicity of human malignant melanocytes in nude mice in relation to their differentiation in vitro.
J. Natl. Cancer Inst. 64:1029-1040(1980)

PubMed=6539703; DOI=10.1016/0277-5379(84)90015-4
Weinreb A., Travo P.
Discrimination between human melanoma cell lines by fluorescence anisotropy.
Eur. J. Cancer Clin. Oncol. 20:673-677(1984)

PubMed=2344628; DOI=10.1016/S0309-1651(05)80010-4
Aubery M., Reynier M., Lopez M., Ogier-Denis E., Font J., Bardin F.
WGA binding to the surface of two autologous human melanoma cell lines: different expression of sialyl and N-acetylglucosaminyl residues.
Cell Biol. Int. Rep. 14:275-286(1990)

PubMed=10709110; DOI=10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O
McLaughlin P.M.J., Helfrich W., Kok K., Mulder M., Hu S.W., Brinker M.G.L., Ruiters M.H.J., de Leij L.F.M.H., Buys C.H.C.M.
The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines.
Int. J. Cancer 85:871-876(2000)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections DSMZ; ACC-237
Cell line databases/resources CLDB; cl2625
CCLE; IGR37_SKIN
Cell_Model_Passport; SIDM01066
Cosmic-CLP; 1240153
DepMap; ACH-000650
LINCS_LDP; LCL-1248
Ontologies BTO; BTO:0005747
CLO; CLO_0006670
EFO; EFO_0006597
Biological sample resources BioSample; SAMN03472906
BioSample; SAMN10988387
Chemistry resources ChEMBL-Cells; CHEMBL3308435
ChEMBL-Targets; CHEMBL613985
GDSC; 1240153
PharmacoDB; IGR37_652_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM557941
GEO; GSM887158
GEO; GSM888230
GEO; GSM1669928
Other Wikidata; Q54897367
Polymorphism and mutation databases Cosmic; 888064
Cosmic; 1995453
LiGeA; CCLE_202
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number27