Cellosaurus IGR-37 (CVCL_2075)

Cell line name IGR-37
Synonyms IgR-37; IGR 37; IGR37; MM1
Accession CVCL_2075
Resource Identification Initiative To cite this cell line use: IGR-37 (RRID:CVCL_2075)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~48-72 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Melanoma (NCIt: C3224)
Derived from metastatic site: Groin lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2076 ! IGR-39
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO11,12
D13S31712
D16S53911
D18S5114,15
D21S1131.2,32.2
D3S135817,18
D5S81811,12
D7S82010,11
D8S117914,15
FGA22
Penta D9
Penta E12,16
TH019
TPOX8,11
vWA17,21
Publications

PubMed=405430; DOI=10.1111/1523-1747.ep12496554
Foa C., Aubert C.
Cellular localization of tyrosinase in human malignant melanoma cell lines.
J. Invest. Dermatol. 68:369-378(1977)

PubMed=6929009; DOI=10.1093/jnci/64.5.1029
Aubert C., Rouge F., Galindo J.R.
Tumorigenicity of human malignant melanocytes in nude mice in relation to their differentiation in vitro.
J. Natl. Cancer Inst. 64:1029-1040(1980)

PubMed=6539703; DOI=10.1016/0277-5379(84)90015-4
Weinreb A., Travo P.
Discrimination between human melanoma cell lines by fluorescence anisotropy.
Eur. J. Cancer Clin. Oncol. 20:673-677(1984)

PubMed=2344628; DOI=10.1016/S0309-1651(05)80010-4
Aubery M., Reynier M., Lopez M., Ogier-Denis E., Font J., Bardin F.
WGA binding to the surface of two autologous human melanoma cell lines: different expression of sialyl and N-acetylglucosaminyl residues.
Cell Biol. Int. Rep. 14:275-286(1990)

PubMed=10709110; DOI=10.1002/(SICI)1097-0215(20000315)85:6<871::AID-IJC22>3.0.CO;2-O
McLaughlin P.M.J., Helfrich W., Kok K., Mulder M., Hu S.W., Brinker M.G.L., Ruiters M.H.J., de Leij L.F.M.H., Buys C.H.C.M.
The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines.
Int. J. Cancer 85:871-876(2000)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-237
Cell line databases/resources CLDB; cl2625
CCLE; IGR37_SKIN
Cosmic-CLP; 1240153
GDSC; 1240153
LINCS_LDP; LCL-1248
Ontologies BTO; BTO:0005747
CLO; CLO_0006670
EFO; EFO_0006597
Biological sample resources BioSample; SAMN03472906
Chemistry resources ChEMBL-Cells; CHEMBL3308435
ChEMBL-Targets; CHEMBL613985
Gene expression databases GEO; GSM557941
GEO; GSM887158
GEO; GSM888230
GEO; GSM1669928
Polymorphism and mutation databases Cosmic; 888064
Cosmic; 1995453