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Cellosaurus JL-1 (CVCL_2080)

[Text version]

Cell line name JL-1
Synonyms JL1
Accession CVCL_2080
Resource Identification Initiative To cite this cell line use: JL-1 (RRID:CVCL_2080)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: TCGA-110-CL cell line panel.
Doubling time: 47 hours (PubMed=23840376); ~70-80 hours (DSMZ).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.03
Native American0
East Asian, North3.05
East Asian, South0
South Asian2.74
European, North56.74
European, South37.42
Disease Pleural epithelioid mesothelioma (NCIt: C45662)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 54Y
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10
D3S135818
D5S81812,13
D7S8209,11
D8S117915
D13S3179
D16S5399,12
D18S5114,15
D21S1130
FGA22,23
Penta D11,12
Penta E11,13
TH018,9.3
TPOX9,11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=15372243; DOI=10.1007/s00418-004-0701-1
Philippeaux M.-M., Pache J.-C., Dahoun S., Barnet M., Robert J.-H., Mauel J., Spiliopoulos A.
Establishment of permanent cell lines purified from human mesothelioma: morphological aspects, new marker expression and karyotypic analysis.
Histochem. Cell Biol. 122:249-260(2004)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23840376; DOI=10.1371/journal.pone.0065903
Szulkin A., Nilsonne G., Mundt F., Wasik A.M., Souri P., Hjerpe A., Dobra K.
Variation in drug sensitivity of malignant mesothelioma cell lines with substantial effects of selenite and bortezomib, highlights need for individualized therapy.
PLoS ONE 8:E65903-E65903(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574-3574(2019)

Cross-references
Cell line collections DSMZ; ACC-596
Cell line databases/resources CCLE; JL1_PLEURA
DepMap; ACH-000645
Ontologies EFO; EFO_0006448
Biological sample resources BioSample; SAMN03473060
BioSample; SAMN10988459
Chemistry resources PharmacoDB; JL1_708_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM887185
GEO; GSM888258
Other Wikidata; Q54898973
Polymorphism and mutation databases LiGeA; CCLE_059
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-2020
Version number21