Cell line name | JURL-MK1 | ||||||||||||||||||
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Accession | CVCL_2086 | ||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: JURL-MK1 (RRID:CVCL_2086) | ||||||||||||||||||
Comments | Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Doubling time: 48 hours (PubMed=9305612); ~48 hours (DSMZ). Microsatellite instability: Stable (MSS) (Sanger). Omics: Deep exome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: SNP array analysis. Omics: Transcriptome analysis. Derived from sampling site: Peripheral blood. | ||||||||||||||||||
Sequence variations | Gene fusion; BCR-ABL1 (PubMed=9305612; DepMap).Homozygous for KMT2D p.Tyr1495Ter (c.4485C>A) (ClinVar=VCV000521871) (CCLE; Cosmic-CLP).Homozygous for TP53 p.Arg306Ter (c.916C>T) (ClinVar=VCV000142144) (CCLE; Cosmic-CLP). | ||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
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Disease | Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174) Chronic myeloid leukemia (ORDO: Orphanet_521) | ||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Originate from same individual | CVCL_2087 ! JURL-MK2 | ||||||||||||||||||
Sex of cell | Male | ||||||||||||||||||
Age at sampling | 73Y | ||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||
STR profile | Source(s): Cosmic-CLP; DSMZ Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||
Publications | PubMed=9305612; DOI=10.1038/sj.leu.2400760 DOI=10.1016/B978-0-12-221970-2.50457-5 PubMed=16408098; DOI=10.1038/sj.leu.2404081 PubMed=22460905; DOI=10.1038/nature11003 PubMed=27397505; DOI=10.1016/j.cell.2016.06.017 PubMed=30285677; DOI=10.1186/s12885-018-4840-5 PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 | ||||||||||||||||||
Cross-references | |||||||||||||||||||
Cell line collections | DSMZ; ACC-532 | ||||||||||||||||||
Cell line databases/resources | CCLE; JURLMK1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM01015 CGH-DB; 9214-4 Cosmic-CLP; 1327771 DepMap; ACH-000326 LINCS_LDP; LCL-1101 | ||||||||||||||||||
Ontologies | BTO; BTO:0005909 | ||||||||||||||||||
Biological sample resources | BioSample; SAMN03473526
BioSample; SAMN10988501 | ||||||||||||||||||
Chemistry resources | GDSC; 1327771
PharmacoDB; JURLMK1_714_2019 | ||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610 GEO; GSM887189 GEO; GSM888262 GEO; GSM1669966 | ||||||||||||||||||
Other | Wikidata; Q54899164 | ||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 1012073
Cosmic; 1078719 IARC_TP53; 28238 LiGeA; CCLE_124 Progenetix; CVCL_2086 | ||||||||||||||||||
Entry history | |||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||
Version number | 25 |