Cellosaurus KCL-22 (CVCL_2091)

Cell line name KCL-22
Synonyms KCL22; Kcl22; KCL22S
Accession CVCL_2091
Resource Identification Initiative To cite this cell line use: KCL-22 (RRID:CVCL_2091)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 24 hours (PubMed=6321612); ~24 hours (DSMZ).
Microsatellite instability: Instable (MSI-high) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Proteome analysis by 2D-DE/MS.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Pleural effusion.
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_DP58 (KCL22-r)CVCL_4V46 (KCL22/SR)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; JCRB

Markers:
AmelogeninX
CSF1PO12
D13S3178,11 (Cosmic-CLP; DSMZ)
8,12 (JCRB)
D16S53912
D5S81810,12 (Cosmic-CLP; DSMZ)
10,11 (JCRB)
D7S82012 (Cosmic-CLP; DSMZ)
11,12 (JCRB)
TH017,9
TPOX8
vWA14
Publications

PubMed=6321612; DOI=10.1002/stem.5530010205
Kubonishi I., Miyoshi I.
Establishment of a Ph1 chromosome-positive cell line from chronic myelogenous leukemia in blast crisis.
Int. J. Cell Cloning 1:105-117(1983)

PubMed=6576961; DOI=10.20772/cancersci1959.74.3_319
Kubonishi I., Machida K.-I., Sonobe H., Ohtsuki Y., Akagi T., Miyoshi I.
Two new human myeloid cell lines derived from acute promyelocytic leukemia and chronic myelocytic leukemia.
Gann 74:319-322(1983)

PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9
Keating A.
Ph positive CML cell lines.
Baillieres Clin. Haematol. 1:1021-1029(1987)

PubMed=20417730; DOI=10.1016/j.bbapap.2010.04.009
Colavita I., Esposito N., Martinelli R., Catanzano F., Melo J.V., Pane F., Ruoppolo M., Salvatore F.
Gaining insights into the Bcr-Abl activity-independent mechanisms of resistance to imatinib mesylate in KCL22 cells: a comparative proteomic approach.
Biochim. Biophys. Acta 1804:1974-1987(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23754495; DOI=10.1002/pmic.201200444
Colavita I., Esposito N., Quintarelli C., Nigro E., Pane F., Ruoppolo M., Salvatore F.
Identification of annexin A1 interacting proteins in chronic myeloid leukemia KCL22 cells.
Proteomics 13:2414-2418(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-519
JCRB; JCRB1317
JCRB; NIHS0534 - Discontinued
NCBI_Iran; C574
Cell line databases/resources CCLE; KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 1330931
GDSC; 1330931
LINCS_LDP; LCL-1105
Ontologies BTO; BTO:0004137
Biological sample resources BioSample; SAMN03472399
BioSample; SAMN03473517
Gene expression databases GEO; GSM887202
GEO; GSM888275
GEO; GSM1669981
Polymorphism and mutation databases Cosmic; 919142
Cosmic; 924053
Cosmic; 1019832
Cosmic; 1026566
Cosmic; 1070700
Cosmic; 1078720
Cosmic; 1176585
Cosmic; 1436596
Cosmic; 1498417
Cosmic; 2009517
Proteomic databases PRIDE; PXD000030