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Cellosaurus KCL-22 (CVCL_2091)

[Text version]

Cell line name KCL-22
Synonyms KCL22; Kcl22; KCL22S
Accession CVCL_2091
Resource Identification Initiative To cite this cell line use: KCL-22 (RRID:CVCL_2091)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Doubling time: 24 hours (PubMed=6321612); ~24 hours (DSMZ).
Microsatellite instability: Instable (MSI-high) (PubMed=9510473; PubMed=31068700; Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Proteome analysis by 2D-DE/MS.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Pleural effusion.
Sequence variations BCR-ABL1 gene fusion.
Heterozygous for MSH6 p.Phe1088Serfs*2 (c.3261delC) and p.Phe1088Leufs*5 (c.3261dupC) (3261_3262insC) (PubMed=9510473).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.5
East Asian, North75.25
East Asian, South24.24
South Asian0
European, North0
European, South0
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_DP58 (KCL22-r)CVCL_4V46 (KCL22/SR)
Sex of cell Female
Age at sampling 32Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; JCRB

Markers:
AmelogeninX
CSF1PO12
D5S81810,12 (Cosmic-CLP; DSMZ)
10,11 (JCRB)
D7S82012 (Cosmic-CLP; DSMZ)
11,12 (JCRB)
D13S3178,11 (Cosmic-CLP; DSMZ)
8,12 (JCRB)
D16S53912
TH017,9
TPOX8
vWA14

Run an STR similarity search on this cell line
Publications

PubMed=6321612; DOI=10.1002/stem.5530010205
Kubonishi I., Miyoshi I.
Establishment of a Ph1 chromosome-positive cell line from chronic myelogenous leukemia in blast crisis.
Int. J. Cell Cloning 1:105-117(1983)

PubMed=6576961; DOI=10.20772/cancersci1959.74.3_319
Kubonishi I., Machida K.-I., Sonobe H., Ohtsuki Y., Akagi T., Miyoshi I.
Two new human myeloid cell lines derived from acute promyelocytic leukemia and chronic myelocytic leukemia.
Gann 74:319-322(1983)

PubMed=3332852; DOI=10.1016/S0950-3536(87)80037-9
Keating A.
Ph positive CML cell lines.
Baillieres Clin. Haematol. 1:1021-1029(1987)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x
Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H.
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=20417730; DOI=10.1016/j.bbapap.2010.04.009
Colavita I., Esposito N., Martinelli R., Catanzano F., Melo J.V., Pane F., Ruoppolo M., Salvatore F.
Gaining insights into the Bcr-Abl activity-independent mechanisms of resistance to imatinib mesylate in KCL22 cells: a comparative proteomic approach.
Biochim. Biophys. Acta 1804:1974-1987(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23754495; DOI=10.1002/pmic.201200444
Colavita I., Esposito N., Quintarelli C., Nigro E., Pane F., Ruoppolo M., Salvatore F.
Identification of annexin A1 interacting proteins in chronic myeloid leukemia KCL22 cells.
Proteomics 13:2414-2418(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940-940(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections DSMZ; ACC-519
JCRB; JCRB1317
JCRB; NIHS0534 - Discontinued
NCBI_Iran; C574
Cell line databases/resources CCLE; KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM01004
Cosmic-CLP; 1330931
DepMap; ACH-000983
GDSC; 1330931
LINCS_LDP; LCL-1105
Ontologies BTO; BTO:0004137
Biological sample resources BioSample; SAMN03472399
BioSample; SAMN03473517
BioSample; SAMN10988558
Chemistry resources PharmacoDB; KCL22_739_2019
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM887202
GEO; GSM888275
GEO; GSM1669981
Other Wikidata; Q54899647
Polymorphism and mutation databases Cosmic; 919142
Cosmic; 924053
Cosmic; 1019832
Cosmic; 1026566
Cosmic; 1070700
Cosmic; 1078720
Cosmic; 1176585
Cosmic; 1436596
Cosmic; 1498417
Cosmic; 2009517
LiGeA; CCLE_363
Proteomic databases PRIDE; PXD000030
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number22