ID   Kelly
AC   CVCL_2092
AS   CVCL_B322
SY   KELLY; NB19; NB-19; NB19-RIKEN
DR   BTO; BTO:0006213
DR   CLO; CLO_0007091
DR   CLO; CLO_0051540
DR   EFO; EFO_0002069
DR   CLDB; cl3020
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   BioGRID_ORCS_Cell_line; 623
DR   BioSample; SAMN03472324
DR   BioSample; SAMN03473084
DR   BioSample; SAMN03473316
DR   BioSample; SAMN10988299
DR   cancercelllines; CVCL_2092
DR   Cell_Model_Passport; SIDM01009
DR   ChEMBL-Cells; CHEMBL4651376
DR   CLS; 300317
DR   Cosmic; 688077
DR   Cosmic; 753618
DR   Cosmic; 801738
DR   Cosmic; 920246
DR   Cosmic; 947704
DR   Cosmic; 1037341
DR   Cosmic; 1099138
DR   Cosmic; 1109365
DR   Cosmic; 1153786
DR   Cosmic; 1161990
DR   Cosmic; 1167409
DR   Cosmic; 1167987
DR   Cosmic; 1212537
DR   Cosmic; 1995468
DR   Cosmic; 2058107
DR   Cosmic; 2131576
DR   Cosmic; 2393634
DR   Cosmic; 2485945
DR   Cosmic-CLP; 753618
DR   DepMap; ACH-000259
DR   DSMZ; ACC-355
DR   DSMZCellDive; ACC-355
DR   ECACC; 92110411
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 753618
DR   GEO; GSM313806
DR   GEO; GSM333801
DR   GEO; GSM313805
DR   GEO; GSM563354
DR   GEO; GSM887206
DR   GEO; GSM888279
DR   GEO; GSM1366407
DR   GEO; GSM1669983
DR   GEO; GSM2371238
DR   GEO; GSM2394386
DR   GEO; GSM3145714
DR   GEO; GSM4104577
DR   GEO; GSM4104578
DR   GEO; GSM4104626
DR   GEO; GSM4104627
DR   GEO; GSM4105308
DR   GEO; GSM4105309
DR   GEO; GSM4105310
DR   GEO; GSM4105311
DR   GEO; GSM4105312
DR   IARC_TP53; 28354
DR   LiGeA; CCLE_776
DR   LINCS_LDP; LCL-1966
DR   Lonza; 1024
DR   PharmacoDB; KELLY_743_2019
DR   PRIDE; PXD003596
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_2092
DR   Progenetix; CVCL_B322
DR   PubChem_Cell_line; CVCL_2092
DR   RCB; RCB0479
DR   Wikidata; Q54899802
RX   DOI=10.1007/0-306-46872-7_2;
RX   PubMed=2846152;
RX   PubMed=6888561;
RX   PubMed=7139592;
RX   PubMed=10630978;
RX   PubMed=11668190;
RX   PubMed=17506115;
RX   PubMed=18082704;
RX   PubMed=18724359;
RX   PubMed=18923524;
RX   PubMed=22460905;
RX   PubMed=24466371;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=28350380;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=33525507;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Population: Caucasian.
CC   Characteristics: MYCN-amplified NBL cell line.
CC   Virology: Infected with a murine leukemia virus-related virus (PubMed=30629668).
CC   Doubling time: ~30 hours (CLS=300317); ~30-40 hours (DSMZ=ACC-355).
CC   HLA typing: A*01:01,01:01; B*08:01,51:01; C*03:03,07:01; DQA1*03:02,03:02; DRB1*07:01,12:01 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Heterozygous (PubMed=18724359; PubMed=28350380; Cosmic-CLP; DepMap).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro177Thr (c.529C>A); ClinVar=VCV000482220; Zygosity=Homozygous (Cosmic-CLP; DepMap).
CC   Omics: Chromatin accessibility by ATAC-seq.
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: H3K27ac ChIP-seq epigenome analysis.
CC   Omics: H3K27me3 ChIP-seq epigenome analysis.
CC   Omics: H3K4me1 ChIP-seq epigenome analysis.
CC   Omics: H3K4me3 ChIP-seq epigenome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Omics: Transcriptome analysis by single cell RNAseq.
CC   Genome ancestry: African=2.15%; Native American=0%; East Asian, North=2.95%; East Asian, South=0%; South Asian=0%; European, North=61.68%; European, South=33.22% (PubMed=30894373).
CC   Discontinued: RCB; RCB0479; probable.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
ST   Source(s): Cosmic-CLP; DSMZ; ECACC; PubMed=25877200; RCB
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 10,14 (ECACC; RCB)
ST   D13S317: 14 (Cosmic-CLP; DSMZ; PubMed=25877200)
ST   D16S539: 12,13
ST   D18S51: 14,17
ST   D19S433: 12,16
ST   D21S11: 28,30
ST   D2S1338: 17,20
ST   D3S1358: 14,16
ST   D5S818: 11,13
ST   D7S820: 9
ST   D8S1179: 14
ST   FGA: 20,21
ST   Penta D: 9,14
ST   Penta E: 12,16
ST   TH01: 9.3
ST   TPOX: 8,10
ST   vWA: 16,18 (ECACC; RCB)
ST   vWA: 18 (Cosmic-CLP; DSMZ; PubMed=25877200)
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   1Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 39
//
RX   DOI=10.1007/0-306-46872-7_2;
RA   Thiele C.J.;
RT   "Neuroblastoma.";
RL   (In) Human cell culture. Vol. 1. Cancer Cell Lines part 1; Masters J.R.W., Palsson B.O. (eds.); pp.21-53; Kluwer Academic Publishers; New York (1999).
//
RX   PubMed=2846152;
RA   Preis P.N., Saya H., Nadasdi L., Hochhaus G., Levin V., Sadee W.;
RT   "Neuronal cell differentiation of human neuroblastoma cells by
RT   retinoic acid plus herbimycin A.";
RL   Cancer Res. 48:6530-6534(1988).
//
RX   PubMed=6888561; DOI=10.1038/305245a0;
RA   Schwab M., Alitalo K., Klempnauer K.-H., Varmus H.E., Bishop J.M.,
RA   Gilbert F., Brodeur G.M., Goldstein M.N., Trent J.M.;
RT   "Amplified DNA with limited homology to myc cellular oncogene is
RT   shared by human neuroblastoma cell lines and a neuroblastoma tumour.";
RL   Nature 305:245-248(1983).
//
RX   PubMed=7139592; DOI=10.1016/0165-4608(82)90105-4;
RA   Gilbert F., Balaban G.B., Moorhead P.S., Bianchi D., Schlesinger H.R.;
RT   "Abnormalities of chromosome 1p in human neuroblastoma tumors and cell
RT   lines.";
RL   Cancer Genet. Cytogenet. 7:33-42(1982).
//
RX   PubMed=10630978; DOI=10.1667/0033-7587(2000)153[0062:FORIMI]2.0.CO;2;
RA   Akudugu J.M., Slabbert J.P., Serafin A., Bohm L.;
RT   "Frequency of radiation-induced micronuclei in neuronal cells does not
RT   correlate with clonogenic survival.";
RL   Radiat. Res. 153:62-67(2000).
//
RX   PubMed=11668190; DOI=10.1177/002215540104901105;
RA   Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.;
RT   "Immunocytochemical analysis of cell lines derived from solid
RT   tumors.";
RL   J. Histochem. Cytochem. 49:1369-1378(2001).
//
RX   PubMed=17506115; DOI=10.1002/nbm.1181;
RA   Peet A.C., McConville C.M., Wilson M.P., Levine B.A., Reed M., Dyer S.A.,
RA   Edwards E.C., Strachan M.C., McMullan D.J., Wilkes T.M., Grundy R.G.;
RT   "1H MRS identifies specific metabolite profiles associated with
RT   MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell
RT   lines.";
RL   NMR Biomed. 20:692-700(2007).
//
RX   PubMed=18082704; DOI=10.1016/j.jpedsurg.2007.08.026;
RA   Komuro H., Saihara R., Shinya M., Takita J., Kaneko S., Kaneko M.,
RA   Hayashi Y.;
RT   "Identification of side population cells (stem-like cell population)
RT   in pediatric solid tumor cell lines.";
RL   J. Pediatr. Surg. 42:2040-2045(2007).
//
RX   PubMed=18724359; DOI=10.1038/nature07261;
RA   Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A.,
RA   Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P.,
RA   Laureys G., Speleman F., Kim C., Hou C.-P., Hakonarson H., Torkamani A.,
RA   Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M.,
RA   Maris J.M.;
RT   "Identification of ALK as a major familial neuroblastoma
RT   predisposition gene.";
RL   Nature 455:930-935(2008).
//
RX   PubMed=18923524; DOI=10.1038/nature07399;
RA   Chen Y.-Y., Takita J., Choi Y.L., Kato M., Ohira M., Sanada M.,
RA   Wang L.-L., Soda M., Kikuchi A., Igarashi T., Nakagawara A.,
RA   Hayashi Y., Mano H., Ogawa S.;
RT   "Oncogenic mutations of ALK kinase in neuroblastoma.";
RL   Nature 455:971-974(2008).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=24466371; DOI=10.1593/tlo.13544;
RA   Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J.,
RA   Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A.,
RA   Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.;
RT   "Testing of SNS-032 in a panel of human neuroblastoma cell lines with
RT   acquired resistance to a broad range of drugs.";
RL   Transl. Oncol. 6:685-696(2013).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28350380; DOI=10.1038/sdata.2017.33;
RA   Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L.,
RA   Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.;
RT   "Transcriptomic profiling of 39 commonly-used neuroblastoma cell
RT   lines.";
RL   Sci. Data 4:170033-170033(2017).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404;
RA   Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.;
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:E0210404-E0210404(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=33525507; DOI=10.3390/biom11020177;
RA   Mercatelli D., Balboni N., Palma A., Aleo E., Sanna P.P., Perini G.,
RA   Giorgi F.M.;
RT   "Single-cell gene network analysis and transcriptional landscape of
RT   MYCN-amplified neuroblastoma cell lines.";
RL   Biomolecules 11:177.1-177.18(2021).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//