Cell line name | KPL-1 | ||||||||||||||||||||
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Synonyms | KPL1 | ||||||||||||||||||||
Accession | CVCL_2094 | ||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: KPL-1 (RRID:CVCL_2094) | ||||||||||||||||||||
Comments | Problematic cell line: Contaminated. Shown to be a MCF-7 derivative (PubMed=20143388). Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: JFCR45 cancer cell line panel. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00325. Population: Caucasian. Doubling time: ~50 hours (DSMZ). Microsatellite instability: Stable (MSS) (PubMed=15677628). Omics: Deep exome analysis. Omics: Deep quantitative proteome analysis. Omics: Deep RNAseq analysis. Omics: SNP array analysis. Omics: Transcriptome analysis. | ||||||||||||||||||||
Sequence variations | Gene deletion; CDKN2A; Zygosity=Homozygous (from parent cell line).Heterozygous for GATA3 p.Asp336Glyfs*17 (c.1006dupG) (from parent cell line).Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (PubMed=28889351). | ||||||||||||||||||||
Genome ancestry | Source: PubMed=30894373
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Disease | Invasive ductal carcinoma, not otherwise specified (NCIt: C4194) Derived from metastatic site: Pleural effusion. | ||||||||||||||||||||
Species of origin | Homo sapiens (Human)
(NCBI Taxonomy: 9606)
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Hierarchy | Parent: CVCL_0031 (MCF-7) | ||||||||||||||||||||
Sex of cell | Female | ||||||||||||||||||||
Age at sampling | 69Y | ||||||||||||||||||||
Category | Cancer cell line | ||||||||||||||||||||
STR profile | Source(s): DSMZ; PubMed=28889351 Markers:
Run an STR similarity search on this cell line | ||||||||||||||||||||
Web pages | http://dpsc.ccbr.utoronto.ca/cancer/get_cellline.pl?cellline=KPL-1 http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx | ||||||||||||||||||||
Publications | PubMed=7710953; DOI=10.1038/bjc.1995.163 PubMed=15677628; DOI=10.1093/carcin/bgi032 PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234 PubMed=16142302; DOI=10.3892/ijo.27.4.881 CLPUB00423 PubMed=20143388; DOI=10.1002/ijc.25242 PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458 PubMed=22460905; DOI=10.1038/nature11003 PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224 PubMed=25485619; DOI=10.1038/nbt.3080 PubMed=28889351; DOI=10.1007/s10549-017-4496-x PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747 PubMed=31068700; DOI=10.1038/s41586-019-1186-3 PubMed=31978347; DOI=10.1016/j.cell.2019.12.023 | ||||||||||||||||||||
Cross-references | |||||||||||||||||||||
Cell line collections | DSMZ; ACC-317
NCBI_Iran; C643 | ||||||||||||||||||||
Cell line databases/resources | CCLE; KPL1_BREAST
Cell_Model_Passport; SIDM00147 DepMap; ACH-000028 IGRhCellID; KPL1 LINCS_LDP; LCL-1483 | ||||||||||||||||||||
Ontologies | CLO; CLO_0007118
EFO; EFO_0002221 | ||||||||||||||||||||
Biological sample resources | BioSample; SAMN03151840
BioSample; SAMN03473349 BioSample; SAMN10987693 | ||||||||||||||||||||
Chemistry resources | PharmacoDB; KPL1_790_2019 | ||||||||||||||||||||
Gene expression databases | ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-2706 ArrayExpress; E-MTAB-2770 GEO; GSM217583 GEO; GSM274642 GEO; GSM274643 GEO; GSM344368 GEO; GSM344418 GEO; GSM459707 GEO; GSM459720 GEO; GSM459721 GEO; GSM783974 GEO; GSM887238 GEO; GSM888312 GEO; GSM1374603 | ||||||||||||||||||||
Other | Wikidata; Q54900436 | ||||||||||||||||||||
Polymorphism and mutation databases | Cosmic; 2165023
Cosmic; 2750517 LiGeA; CCLE_342 Progenetix; CVCL_2094 | ||||||||||||||||||||
Entry history | |||||||||||||||||||||
Entry creation | 04-Apr-2012 | ||||||||||||||||||||
Last entry update | 12-Jan-2021 | ||||||||||||||||||||
Version number | 31 |