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Cellosaurus MKPL-1 (CVCL_2116)

[Text version]
Cell line name MKPL-1
Accession CVCL_2116
Resource Identification Initiative To cite this cell line use: MKPL-1 (RRID:CVCL_2116)
Comments Part of: LL-100 blood cancer cell line panel.
Population: Japanese.
Doubling time: 30 hours (PubMed=1602796); ~50-60 hours (DSMZ=ACC-697).
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Gene fusion; HGNC; 2433; CSF1R + HGNC; 9903; RBM6; Name(s)=RBM6-CSF1R (PubMed=17360941).
HLA typing Source: DSMZCellDive=ACC-697
Class I
HLA-AA*24:02:01,31:01:02
HLA-BB*07:02:01,56:01:01
HLA-CC*04:01:01,07:02:01
Disease Adult acute megakaryoblastic leukemia (NCIt: C7965)
Acute megakaryoblastic leukemia (ORDO: Orphanet_518)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): DSMZ; JCRB

Markers:
AmelogeninX
CSF1PO10,12
D2S133819,23
D3S135816,17
D5S81811,12
D7S82011
D8S117913
D13S3178,11
D16S5399
D18S5114
D19S43314,14.2
D21S1129,31.2
FGA19,24
Penta D9,10
Penta E5,17
TH018,9.3
TPOX10,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=1602796
Takeuchi S., Sugito S., Uemura Y., Miyagi T., Kubonishi I., Taguchi H., Enzan H., Ohtsuki Y., Miyoshi I.
Acute megakaryoblastic leukemia: establishment of a new cell line (MKPL-1) in vitro and in vivo.
Leukemia 6:588-594(1992)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=17360941; DOI=10.1182/blood-2006-10-052282
Gu T.-L., Mercher T., Tyner J.W., Goss V.L., Walters D.K., Cornejo M.G., Reeves C., Popova L., Lee K., Heinrich M.C., Rush J., Daibata M., Miyoshi I., Gilliland D.G., Druker B.J., Polakiewicz R.D.
A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia.
Blood 110:323-333(2007)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-697
JCRB; JCRB1325
JCRB; NIHS0536 - Discontinued
Cell line databases/resources DSMZCellDive; ACC-697
Biological sample resources BioSample; SAMN03473446
Encyclopedic resources Wikidata; Q54905835
Gene expression databases ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
Polymorphism and mutation databases Cosmic; 787452
Cosmic; 975270
Cosmic; 1012091
Cosmic; 1281328
Cosmic; 2306219
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number20