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Cellosaurus MKPL-1 (CVCL_2116)

[Text version]

Cell line name MKPL-1
Accession CVCL_2116
Resource Identification Initiative To cite this cell line use: MKPL-1 (RRID:CVCL_2116)
Comments Part of: LL-100 blood cancer cell line panel.
Doubling time: 30 hours (PubMed=1602796); ~50-60 hours (DSMZ).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Derived from sampling site: Bone marrow.
Sequence variations RBM6-CSF1R gene fusion (PubMed=17360941).
Disease Adult acute megakaryoblastic leukemia (NCIt: C7965)
Acute megakaryoblastic leukemia (ORDO: Orphanet_518)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): DSMZ; JCRB

Markers:
AmelogeninX
CSF1PO10,12
D5S81811,12
D7S82011
D13S3178,11
D16S5399
TH018,9.3
TPOX10,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=1602796
Takeuchi S., Sugito S., Uemura Y., Miyagi T., Kubonishi I., Taguchi H., Enzan H., Ohtsuki Y., Miyoshi I.
Acute megakaryoblastic leukemia: establishment of a new cell line (MKPL-1) in vitro and in vivo.
Leukemia 6:588-594(1992)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=17360941; DOI=10.1182/blood-2006-10-052282
Gu T.-L., Mercher T., Tyner J.W., Goss V.L., Walters D.K., Cornejo M.G., Reeves C., Popova L., Lee K., Heinrich M.C., Rush J., Daibata M., Miyoshi I., Gilliland D.G., Druker B.J., Polakiewicz R.D.
A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia.
Blood 110:323-333(2007)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections DSMZ; ACC-697
JCRB; JCRB1325
JCRB; NIHS0536 - Discontinued
Biological sample resources BioSample; SAMN03473446
Gene expression databases ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
Other Wikidata; Q54905835
Polymorphism and mutation databases Cosmic; 787452
Cosmic; 975270
Cosmic; 1012091
Cosmic; 1281328
Cosmic; 2306219
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-2020
Version number14