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Cellosaurus MOTN-1 (CVCL_2127)

[Text version]

Cell line name MOTN-1
Synonyms MOTN1
Accession CVCL_2127
Resource Identification Initiative To cite this cell line use: MOTN-1 (RRID:CVCL_2127)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: LL-100 blood cancer cell line panel.
Characteristics: IL2 dependent.
Doubling time: 24 hours (PubMed=12127564); ~30-40 hours (DSMZ).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations TBL1XR1-TP63 gene fusion (PubMed=31160637).
Homozygous for TP53 c.782+1G>A; splice donor mutation (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.84
Native American0.4
East Asian, North73.72
East Asian, South24.39
South Asian0
European, North0
European, South0.64
Disease T-cell large granular lymphocyte leukemia (NCIt: C4664)
T-cell large granular lymphocyte leukemia (ORDO: Orphanet_86872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L208 ! PLT-2
Sex of cell Female
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX
CSF1PO12,13
D5S81810
D7S82010,12
D13S31712
D16S5399,11
TH016
TPOX11
vWA14,19

Run an STR similarity search on this cell line
Publications

PubMed=12127564; DOI=10.1016/S0145-2126(02)00023-1
Matsuo Y., Drexler H.G., Takeuchi M., Tanaka M., Orita K.
Establishment of the T-cell large granular lymphocyte leukemia cell line MOTN-1 carrying natural killer-cell antigens.
Leuk. Res. 26:873-879(2002)

PubMed=14712486; DOI=10.1002/ijc.11647
Daibata M., Matsuo Y., Machida H., Taguchi T., Ohtsuki Y., Taguchi H.
Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phases of CD56+ T-cell large granular lymphocyte leukemia.
Int. J. Cancer 108:845-851(2004)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections DSMZ; ACC-559
Cell line databases/resources CCLE; MOTN1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
DepMap; ACH-001130
Biological sample resources BioSample; SAMN03473538
BioSample; SAMN10988469
Chemistry resources PharmacoDB; MOTN1_963_2019
Gene expression databases ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM887340
GEO; GSM888416
Other Wikidata; Q54906412
Polymorphism and mutation databases IARC_TP53; 28296
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-2020
Version number17