Cellosaurus MOTN-1 (CVCL_2127)

Cell line name MOTN-1
Synonyms MOTN1
Accession CVCL_2127
Resource Identification Initiative To cite this cell line use: MOTN-1 (RRID:CVCL_2127)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Characteristics: IL2 dependent.
Doubling time: 24 hours (PubMed=12127564); ~30-40 hours (DSMZ).
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease T-cell large granular lymphocyte leukemia (NCIt: C4664)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_L208 ! PLT-2
Sex of cell Female
Category Cancer cell line
STR profile Source(s): DSMZ

Markers:
AmelogeninX
CSF1PO12,13
D13S31712
D16S5399,11
D5S81810
D7S82010,12
TH016
TPOX11
vWA14,19
Publications

PubMed=12127564; DOI=10.1016/S0145-2126(02)00023-1
Matsuo Y., Drexler H.G., Takeuchi M., Tanaka M., Orita K.
Establishment of the T-cell large granular lymphocyte leukemia cell line MOTN-1 carrying natural killer-cell antigens.
Leuk. Res. 26:873-879(2002)

PubMed=14712486; DOI=10.1002/ijc.11647
Daibata M., Matsuo Y., Machida H., Taguchi T., Ohtsuki Y., Taguchi H.
Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phases of CD56+ T-cell large granular lymphocyte leukemia.
Int. J. Cancer 108:845-851(2004)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

Cross-references
Cell line collections DSMZ; ACC-559
Cell line databases/resources CCLE; MOTN1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Biological sample resources BioSample; SAMN03473538
Gene expression databases GEO; GSM887340
GEO; GSM888416