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Cellosaurus MT-3 [Human contaminated breast cancer] (CVCL_2129)

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Cell line name MT-3 [Human contaminated breast cancer]
Synonyms MT3
Accession CVCL_2129
Resource Identification Initiative To cite this cell line use: MT-3 [Human contaminated breast cancer] (RRID:CVCL_2129)
Comments Problematic cell line: Contaminated. Shown to be a LS174T derivative.
Part of: MD Anderson Cell Lines Project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00506.
Doubling time: ~30 hours (DSMZ).
Microsatellite instability: Instable (MSI) (PubMed=12661003; PubMed=15677628).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations CTNNB1 p.Ser45Phe (c.134C>T) (from parent cell line).
Heterozygous for KRAS p.Gly12Asp (c.35G>A) (ClinVar=VCV000012582) (from parent cell line).
PIK3CA p.His1047Arg (c.3140A>G) (ClinVar=VCV000013652) (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1384 (LS174T)
Sex of cell Female
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,13
D3S135815,16
D5S81812,17 (DSMZ)
12 (PubMed=25877200)
D7S82010.3,11,12
D8S117912,15
D13S31710,11
D16S53911,13
D18S5110,12
D21S1129,31
FGA20,21
Penta D9,10
Penta E13,15
TH016,7
TPOX8,9
vWA13,14,17 (DSMZ)
14,17 (PubMed=25877200)

Run an STR similarity search on this cell line
Web pages http://www.pawefish.path.cam.ac.uk/BreastCellLineDescriptions/MT-3.html
http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx
http://tcpaportal.org/mclp/
Publications

PubMed=1446057; DOI=10.1007/BF01831480
Naundorf H., Rewasowa E.C., Fichtner I., Buttner B., Becker M., Gorlich M.
Characterization of two human mammary carcinomas, MT-1 and MT-3, suitable for in vivo testing of ether lipids and their derivatives.
Breast Cancer Res. Treat. 23:87-95(1992)

PubMed=9150904; DOI=10.1023/A:1005756632293
Hambly R.J., Double J.A., Thompson M.J., Bibby M.C.
Establishment and characterisation of new cell lines from human breast tumours initially established as tumour xenografts in NMRI nude mice.
Breast Cancer Res. Treat. 43:247-258(1997)

PubMed=11044355; DOI=10.1054/bjoc.2000.1458
Davidson J.M., Gorringe K.L., Chin S.-F., Orsetti B., Besret C., Courtay-Cahen C., Roberts I., Theillet C., Caldas C., Edwards P.A.W.
Molecular cytogenetic analysis of breast cancer cell lines.
Br. J. Cancer 83:1309-1317(2000)

PubMed=12661003; DOI=10.1002/gcc.10196
Seitz S., Wassmuth P., Plaschke J., Schackert H.K., Karsten U., Santibanez-Koref M.-F., Schlag P.M., Scherneck S.
Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.
Genes Chromosomes Cancer 37:29-35(2003)

PubMed=12800145; DOI=10.1002/gcc.10218
Adelaide J., Huang H.-E., Murati A., Alsop A.E., Orsetti B., Mozziconacci M.-J., Popovici C., Ginestier C., Letessier A., Basset C., Courtay-Cahen C., Jacquemier J., Theillet C., Birnbaum D., Edwards P.A.W., Chaffanet M.
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.
Genes Chromosomes Cancer 37:333-345(2003)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Gorringe K.L., Chin S.-F., Pharoah P., Staines J.M., Oliveira C., Edwards P.A.W., Caldas C.
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y., Mills G.B., Cho R.J., Collisson E.A., van't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections DSMZ; ACC-403
Cell line databases/resources IGRhCellID; MT3
LINCS_HMS; 50031
LINCS_LDP; LCL-1473
Ontologies CLO; CLO_0007890
EFO; EFO_0002241
Biological sample resources BioSample; SAMN03472975
BioSample; SAMN03473582
BioSample; SAMN06481118
Chemistry resources PharmacoDB; MT3_969_2019
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM115102
GEO; GSM217592
GEO; GSM412073
GEO; GSM412084
GEO; GSM412093
GEO; GSM412098
GEO; GSM412106
GEO; GSM412110
GEO; GSM459700
GEO; GSM474280
GEO; GSM474281
GEO; GSM476484
GEO; GSM476485
GEO; GSM478311
GEO; GSM478312
GEO; GSM478314
GEO; GSM478315
GEO; GSM478320
GEO; GSM478321
GEO; GSM783977
GEO; GSM847419
GEO; GSM847498
GEO; GSM844610
GEO; GSM1172986
Other Wikidata; Q54906937
Entry history
Entry creation04-Apr-2012
Last entry updated02-Jul-2020
Version number23