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Cellosaurus NCI-H69/LX4 (CVCL_2140)
[Text version]
Cell line name |
NCI-H69/LX4
|
Synonyms |
NCI H69-LX4; H69/LX4
|
Accession |
CVCL_2140
|
Resource Identification Initiative |
To cite this cell line use: NCI-H69/LX4 (RRID:CVCL_2140) |
Comments |
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
|
Sequence variations |
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325dellGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
|
Disease |
Lung small cell carcinoma (NCIt: C4917) Small cell lung cancer (ORDO: Orphanet_70573) Derived from metastatic site: Pleural effusion.
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Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606)
|
Hierarchy |
Parent: CVCL_1579 (NCI-H69)
|
Sex of cell |
Male
|
Age at sampling |
55Y
|
Category |
Cancer cell line
|
STR profile |
Source(s): ECACC
Markers: Run an STR similarity search on this cell line |
Publications | PubMed=3011054; DOI=10.1038/bjc.1986.83 Twentyman P.R., Fox N.E., Wright K.A., Bleehen N.M. Derivation and preliminary characterisation of adriamycin resistant lines of human lung cancer cells. Br. J. Cancer 53:529-537(1986) PubMed=3034934; DOI=10.1002/jcb.240330405 Ibson J.M., Waters J.J., Twentyman P.R., Bleehen N.M., Rabbitts P.H. Oncogene amplification and chromosomal abnormalities in small cell lung cancer. J. Cell. Biochem. 33:267-288(1987) PubMed=7903701; DOI=10.1093/jnci/86.2.110 Barrand M.A., Heppell-Parton A.C., Wright K.A., Rabbitts P.H., Twentyman P.R. A 190-kilodalton protein overexpressed in non-P-glycoprotein-containing multidrug-resistant cells and its relationship to the MRP gene. J. Natl. Cancer Inst. 86:110-117(1994) |
Cross-references |
Cell line collections |
ECACC; 96042329
|
Encyclopedic resources |
Wikidata; Q54908107
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Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 20-May-2021 |
Version number | 17 |
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