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Cellosaurus NCI-H69/LX4 (CVCL_2140)

[Text version]

Cell line name NCI-H69/LX4
Synonyms NCI H69-LX4; H69/LX4
Accession CVCL_2140
Resource Identification Initiative To cite this cell line use: NCI-H69/LX4 (RRID:CVCL_2140)
Comments Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Sequence variations
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325dellGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1579 (NCI-H69)
Sex of cell Male
Age at sampling 55Y
Category Cancer cell line
STR profile Source(s): ECACC


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PubMed=3011054; DOI=10.1038/bjc.1986.83
Twentyman P.R., Fox N.E., Wright K.A., Bleehen N.M.
Derivation and preliminary characterisation of adriamycin resistant lines of human lung cancer cells.
Br. J. Cancer 53:529-537(1986)

PubMed=3034934; DOI=10.1002/jcb.240330405
Ibson J.M., Waters J.J., Twentyman P.R., Bleehen N.M., Rabbitts P.H.
Oncogene amplification and chromosomal abnormalities in small cell lung cancer.
J. Cell. Biochem. 33:267-288(1987)

PubMed=7903701; DOI=10.1093/jnci/86.2.110
Barrand M.A., Heppell-Parton A.C., Wright K.A., Rabbitts P.H., Twentyman P.R.
A 190-kilodalton protein overexpressed in non-P-glycoprotein-containing multidrug-resistant cells and its relationship to the MRP gene.
J. Natl. Cancer Inst. 86:110-117(1994)

Cell line collections ECACC; 96042329
Encyclopedic resources Wikidata; Q54908107
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number17