ID   NCI-H69/LX4
AC   CVCL_2140
SY   NCI H69-LX4; H69/LX4
DR   cancercelllines; CVCL_2140
DR   ECACC; 96042329
DR   Wikidata; Q54908107
RX   PubMed=3011054;
RX   PubMed=3034934;
RX   PubMed=7903701;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): ECACC
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 12
ST   D16S539: 11
ST   D5S818: 11,13
ST   D7S820: 9
ST   TH01: 8,9
ST   TPOX: 10
ST   vWA: 16,17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1579 ! NCI-H69
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 21
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RX   PubMed=3011054; DOI=10.1038/bjc.1986.83;
RA   Twentyman P.R., Fox N.E., Wright K.A., Bleehen N.M.;
RT   "Derivation and preliminary characterisation of adriamycin resistant
RT   lines of human lung cancer cells.";
RL   Br. J. Cancer 53:529-537(1986).
//
RX   PubMed=3034934; DOI=10.1002/jcb.240330405;
RA   Ibson J.M., Waters J.J., Twentyman P.R., Bleehen N.M., Rabbitts P.H.;
RT   "Oncogene amplification and chromosomal abnormalities in small cell
RT   lung cancer.";
RL   J. Cell. Biochem. 33:267-288(1987).
//
RX   PubMed=7903701; DOI=10.1093/jnci/86.2.110;
RA   Barrand M.A., Heppell-Parton A.C., Wright K.A., Rabbitts P.H.,
RA   Twentyman P.R.;
RT   "A 190-kilodalton protein overexpressed in
RT   non-P-glycoprotein-containing multidrug-resistant cells and its
RT   relationship to the MRP gene.";
RL   J. Natl. Cancer Inst. 86:110-117(1994).
//