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Cellosaurus OCI-M2 (CVCL_2150)

Cell line name OCI-M2
Synonyms OCI M2; OCIM2
Accession CVCL_2150
Resource Identification Initiative To cite this cell line use: OCI-M2 (RRID:CVCL_2150)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: LL-100 blood cancer cell line panel.
From: Ontario Cancer Institute (OCI); Toronto; Canada.
Doubling time: ~36 hours (DSMZ=ACC-619).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Gene fusion; HGNC; 10471; RUNX1 + HGNC; 1268; TSPEAR; Name(s)=RUNX1-TSPEAR (PubMed=31160637).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val274Asp (c.821T>A); ClinVar=VCV000376675; Zygosity=Unspecified (DepMap).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*08:01,44:02
HLA-CC*05:01,07:06

Source: DSMZCellDive=ACC-619
Class I
HLA-AA*02:01:01,02:01:01
HLA-BB*08:01:01,44:02:01
HLA-CC*05:01:01,07:01:01
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): DepMap; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D2S133818,24
D3S135815
D5S81811,12
D7S8208,11
D8S117910,13
D13S31711,14
D16S53911
D18S5116,20
D19S43314
D21S1129
FGA21
Penta D9 (DSMZ; PubMed=25877200)
9,12 (DepMap)
Penta E10,12
TH018,9
TPOX8
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=3166384; DOI=10.1182/blood.V72.3.1029.1029
Papayannopoulou T., Nakamoto B., Kurachi S., Tweeddale M.E., Messner H.A.
Surface antigenic profile and globin phenotype of two new human erythroleukemia lines: characterization and interpretations.
Blood 72:1029-1038(1988)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections (Providers) DSMZ; ACC-619
Cell line databases/resources cancercelllines; CVCL_2150
Cell_Model_Passport; SIDM01841
DepMap; ACH-001618
DSMZCellDive; ACC-619
Anatomy/cell type resources BTO; BTO:0004623
Biological sample resources BioSample; SAMN03473109
Chemistry resources PharmacoDB; OCIM2_1191_2019
Encyclopedic resources Wikidata; Q54931783
Experimental variables resources EFO; EFO_0006713
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM1374792
GEO; GSM1446760
Polymorphism and mutation databases Cosmic; 787472
Cosmic; 924044
Cosmic; 975294
Cosmic; 1012112
Cosmic; 1245830
Cosmic; 1281349
Cosmic; 1465962
Cosmic; 2306236
Cosmic; 2750870
IARC_TP53; 347
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001002554
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number27