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Cellosaurus OCI-M2 (CVCL_2150)

[Text version]

Cell line name OCI-M2
Synonyms OCI M2; OCIM2
Accession CVCL_2150
Resource Identification Initiative To cite this cell line use: OCI-M2 (RRID:CVCL_2150)
Comments Part of: LL-100 blood cancer cell line panel.
From: Ontario Cancer Institute (OCI); Toronto; Canada.
Doubling time: ~36 hours (DSMZ).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Gene fusion; HGNC; 10471; RUNX1 + HGNC; 1268; TSPEAR; Name(s)=RUNX1-TSPEAR (PubMed=31160637).
Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Unspecified (DepMap).
Mutation; HGNC; 11998; TP53; Simple; p.Val274Asp (c.821T>A); ClinVar=VCV000376675; Zygosity=Unspecified (DepMap).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): DepMap; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D3S135815
D5S81811,12
D7S8208,11
D8S117910,13
D13S31711,14
D16S53911
D18S5116,20
D21S1129
FGA21
Penta D9 (PubMed=25877200)
9,12 (DepMap)
Penta E10,12
TH018,9
TPOX8
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=3166384; DOI=10.1182/blood.V72.3.1029.1029
Papayannopoulou T., Nakamoto B., Kurachi S., Tweeddale M.E., Messner H.A.
Surface antigenic profile and globin phenotype of two new human erythroleukemia lines: characterization and interpretations.
Blood 72:1029-1038(1988)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cross-references
Cell line collections DSMZ; ACC-619
Cell line databases/resources DepMap; ACH-001618
Ontologies BTO; BTO:0004623
EFO; EFO_0006713
Biological sample resources BioSample; SAMN03473109
Chemistry resources PharmacoDB; OCIM2_1191_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM1374792
GEO; GSM1446760
Other Wikidata; Q54931783
Polymorphism and mutation databases Cosmic; 787472
Cosmic; 924044
Cosmic; 975294
Cosmic; 1012112
Cosmic; 1245830
Cosmic; 1281349
Cosmic; 1465962
Cosmic; 2306236
Cosmic; 2750870
IARC_TP53; 347
Entry history
Entry creation04-Apr-2012
Last entry update23-Sep-2021
Version number23