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Cellosaurus OCI-M2 (CVCL_2150)

[Text version]

Cell line name OCI-M2
Synonyms OCI M2; OCIM2
Accession CVCL_2150
Resource Identification Initiative To cite this cell line use: OCI-M2 (RRID:CVCL_2150)
Comments Part of: LL-100 blood cancer cell line panel.
From: Ontario Cancer Institute (OCI); Toronto; Canada.
Doubling time: ~36 hours (DSMZ).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Gene fusion; RUNX1-TSPEAR (PubMed=31160637).
NRAS p.Gln61Lys (c.181C>A) (ClinVar=VCV000073058) (DepMap).
TP53 p.Val274Asp (c.821T>A) (ClinVar=VCV000376675) (DepMap).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): DepMap; DSMZ; PubMed=25877200

Penta D9 (PubMed=25877200)
9,12 (DepMap)
Penta E10,12

Run an STR similarity search on this cell line

PubMed=3166384; DOI=10.1182/blood.V72.3.1029.1029
Papayannopoulou T., Nakamoto B., Kurachi S., Tweeddale M.E., Messner H.A.
Surface antigenic profile and globin phenotype of two new human erythroleukemia lines: characterization and interpretations.
Blood 72:1029-1038(1988)

Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

Cell line collections DSMZ; ACC-619
Cell line databases/resources DepMap; ACH-001618
Ontologies BTO; BTO:0004623
EFO; EFO_0006713
Biological sample resources BioSample; SAMN03473109
Chemistry resources PharmacoDB; OCIM2_1191_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM1374792
GEO; GSM1446760
Other Wikidata; Q54931783
Polymorphism and mutation databases Cosmic; 787472
Cosmic; 924044
Cosmic; 975294
Cosmic; 1012112
Cosmic; 1245830
Cosmic; 1281349
Cosmic; 1465962
Cosmic; 2306236
Cosmic; 2750870
Entry history
Entry creation04-Apr-2012
Last entry update12-Jan-2021
Version number21