Cellosaurus PL-21 (CVCL_2161)

Cell line name PL-21
Synonyms PL21
Accession CVCL_2161
Resource Identification Initiative To cite this cell line use: PL-21 (RRID:CVCL_2161)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~40-50 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Acute myeloid leukemia (NCIt: C3171)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; JCRB; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO11,12
D13S3178,11
D16S53911,13
D18S5112,13
D21S1129,30
D3S135815
D5S81810
D7S82012,13
D8S117910
FGA21,24
Penta D11,13
Penta E5,17
TH019
TPOX9,11
vWA14,18
Publications

PubMed=6576961; DOI=10.20772/cancersci1959.74.3_319
Kubonishi I., Machida K.-I., Sonobe H., Ohtsuki Y., Akagi T., Miyoshi I.
Two new human myeloid cell lines derived from acute promyelocytic leukemia and chronic myelocytic leukemia.
Gann 74:319-322(1983)

PubMed=6362749
Kubonishi I., Machida K.-I., Niiya K., Sonobe H., Ohtsuki Y., Iwata K., Miyoshi I.
Establishment of a new peroxidase-positive human myeloid cell line, PL-21.
Blood 63:254-259(1984)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-536
JCRB; JCRB1319
Cell line databases/resources CCLE; PL21_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 1330991
GDSC; 1330991
LINCS_LDP; LCL-1070
Ontologies BTO; BTO:0005928
EFO; EFO_0006473
Biological sample resources BioSample; SAMN01821655
BioSample; SAMN01821714
BioSample; SAMN03473265
Gene expression databases GEO; GSM236801
GEO; GSM236837
GEO; GSM887518
GEO; GSM888600
GEO; GSM1374834
GEO; GSM1446753
GEO; GSM1670351
Polymorphism and mutation databases Cosmic; 787419
Cosmic; 975297
Cosmic; 999725
Cosmic; 1524840
Cosmic; 2131556
Cosmic; 2306237