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Cellosaurus PL-21 (CVCL_2161)

[Text version]

Cell line name PL-21
Synonyms PL21
Accession CVCL_2161
Resource Identification Initiative To cite this cell line use: PL-21 (RRID:CVCL_2161)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 48-64 hours (PubMed=6362749); ~40-50 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations FLT3 internal tandem duplication (FLT3-ITD) (PubMed=12529668).
Heterozygous for KRAS p.Ala176Val (c.437C>T) (CCLE; Cosmic-CLP).
Heterozygous for TP53 p.Pro36fs*8 (c.107delC) (Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American1.5
East Asian, North78.62
East Asian, South18.83
South Asian0
European, North0
European, South1.05
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 24Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; JCRB; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135815
D5S81810
D7S82012,13
D8S117910
D13S3178,11
D16S53911,13
D18S5112,13
D21S1129,30
FGA21,24
Penta D11,13
Penta E5,17
TH019
TPOX9,11
vWA14,18

Run an STR similarity search on this cell line
Publications

PubMed=6576961; DOI=10.20772/cancersci1959.74.3_319
Kubonishi I., Machida K.-I., Sonobe H., Ohtsuki Y., Akagi T., Miyoshi I.
Two new human myeloid cell lines derived from acute promyelocytic leukemia and chronic myelocytic leukemia.
Gann 74:319-322(1983)

PubMed=6362749; DOI=10.1182/blood.V63.2.254.254
Kubonishi I., Machida K.-I., Niiya K., Sonobe H., Ohtsuki Y., Iwata K., Miyoshi I.
Establishment of a new peroxidase-positive human myeloid cell line, PL-21.
Blood 63:254-259(1984)

PubMed=1571549; DOI=10.1182/blood.V79.9.2378.2378
Sugimoto K., Toyoshima H., Sakai R., Miyagawa K., Hagiwara K., Ishikawa F., Takaku F., Yazaki Y., Hirai H.
Frequent mutations in the p53 gene in human myeloid leukemia cell lines.
Blood 79:2378-2383(1992)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

PubMed=12529668; DOI=10.1038/sj.leu.2402740
Quentmeier H., Reinhardt J., Zaborski M., Drexler H.G.
FLT3 mutations in acute myeloid leukemia cell lines.
Leukemia 17:120-124(2003)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940-940(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections DSMZ; ACC-536
JCRB; JCRB1319
Cell line databases/resources CCLE; PL21_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM00450
Cosmic-CLP; 1330991
DepMap; ACH-000218
LINCS_LDP; LCL-1070
Ontologies BTO; BTO:0005928
EFO; EFO_0006473
Biological sample resources BioSample; SAMN01821655
BioSample; SAMN01821714
BioSample; SAMN03473265
BioSample; SAMN10988496
Chemistry resources GDSC; 1330991
PharmacoDB; PL21_1270_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM236801
GEO; GSM236837
GEO; GSM887518
GEO; GSM888600
GEO; GSM1374834
GEO; GSM1446753
GEO; GSM1670351
Other Wikidata; Q54947481
Polymorphism and mutation databases Cosmic; 787419
Cosmic; 975297
Cosmic; 999725
Cosmic; 1524840
Cosmic; 2131556
Cosmic; 2306237
LiGeA; CCLE_483
Entry history
Entry creation04-Apr-2012
Last entry update12-Mar-2020
Version number28