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Cellosaurus SCLC-22H (CVCL_2186)

[Text version]

Cell line name SCLC-22H
Synonyms SCLC22H
Accession CVCL_2186
Resource Identification Initiative To cite this cell line use: SCLC-22H (RRID:CVCL_2186)
Comments Doubling time: 75-85 hours, depending on growth medium (PubMed=3029138); 75 hours (PubMed=2438285); ~48 hours (DSMZ).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Sequence variations Mutation; HGNC; 11998; TP53; Simple; p.Pro278Arg (c.833C>G); ClinVar=VCV000376644; Zygosity=Homozygous (DepMap).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*01:01,32:01
HLA-BB*35:86,27:05
HLA-CC*02:02,02:02
Disease Lung small cell carcinoma (NCIt: C4917)
Small cell lung cancer (ORDO: Orphanet_70573)
Derived from metastatic site: Pericardial effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_0024 ! SCLC-21H
Sex of cell Male
Age at sampling 46Y
Category Cancer cell line
STR profile Source(s): CLS; DepMap; DSMZ

Markers:
AmelogeninX,Y
CSF1PO10
D3S135815
D5S81811,12
D7S82011
D8S117912,13
D13S31712
D16S53912
D18S5114,15
D21S1129,31.2
FGA22 (CLS)
22,23 (DepMap)
Penta D9
Penta E12,13
TH019.3
TPOX8,9
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=2438285; DOI=10.1007/BF00396382
Bepler G., Jaques G., Koehler A., Gropp C., Havemann K.
Markers and characteristics of human SCLC cell lines. Neuroendocrine markers, classical tumor markers, and chromosomal characteristics of permanent human small cell lung cancer cell lines.
J. Cancer Res. Clin. Oncol. 113:253-259(1987)

PubMed=3029138; DOI=10.1007/BF00389964
Bepler G., Jaques G., Neumann K., Aumuller G., Gropp C., Havemann K.
Establishment, growth properties, and morphological characteristics of permanent human small cell lung cancer cell lines.
J. Cancer Res. Clin. Oncol. 113:31-40(1987)

PubMed=2473086; DOI=10.1242/jcs.91.1.91
Broers J.L.V., Rot M.K., Oostendorp T., Bepler G., de Leij L.F.M.H., Carney D.N., Vooijs G.P., Ramaekers F.C.S.
Spontaneous changes in intermediate filament protein expression patterns in lung cancer cell lines.
J. Cell Sci. 91:91-108(1988)

PubMed=1845952; DOI=10.1002/1097-0142(19910201)67:3<619::AID-CNCR2820670317>3.0.CO;2-Y
Broers J.L.V., Mijnheere E.P., Rot M.K., Schaart G., Sijlmans A., Boerman O.C., Ramaekers F.C.S.
Novel antigens characteristic of neuroendocrine malignancies.
Cancer 67:619-633(1991)

PubMed=1320893; DOI=10.1159/000163712
Verbeeck M.A.E., Elands J.P.M., de Leij L.F.M.H., Buys C.H.C.M., Carney D.N., Bepler G., Roebroek A.J.M., van de Ven W.J.M., Burbach J.P.H.
Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines.
Pathobiology 60:136-142(1992)

PubMed=11414198; DOI=10.1007/s004320000207
Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.J.
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Cross-references
Cell line collections CLS; 300445/p505_SCLC-22H
DSMZ; ACC-373
Cell line databases/resources Cell_Model_Passport; SIDM00028
DepMap; ACH-001386
Ontologies CLO; CLO_0008973
EFO; EFO_0006750
Chemistry resources PharmacoDB; SCLC22H_1362_2019
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM784218
Other Wikidata; Q54952445
Polymorphism and mutation databases Progenetix; CVCL_2186
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number27