Home  |  Contact

Cellosaurus SET-2 (CVCL_2187)

[Text version]

Cell line name SET-2
Synonyms Set-2; Set2; SET2
Accession CVCL_2187
Resource Identification Initiative To cite this cell line use: SET-2 (RRID:CVCL_2187)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: ~36 hours (PubMed=10637490); ~60-80 hours (DSMZ).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for JAK2 p.Val617Phe (c.1849G>T) (PubMed=16408098).
Genome ancestry Source: PubMed=30894373

Origin% genome
African7.24
Native American0
East Asian, North78.39
East Asian, South9.7
South Asian0
European, North0
European, South4.67
Disease Adult acute megakaryoblastic leukemia (NCIt: C7965)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D3S135814,16
D5S81811
D7S82010,12
D8S117913,14
D13S3178,10
D16S5399,10
D18S5113,16
D21S1130
FGA19,23
Penta D11
Penta E16,20
TH017,9.3
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=10637490; DOI=10.1038/sj.leu.2401608
Uozumi K., Otsuka M., Ohno N., Moriyama T., Suzuki S., Shimotakahara S., Matsumura I., Hanada S., Arima T.
Establishment and characterization of a new human megakaryoblastic cell line (SET-2) that spontaneously matures to megakaryocytes and produces platelet-like particles.
Leukemia 14:142-152(2000)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940-940(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections DSMZ; ACC-608
Cell line databases/resources CCLE; SET2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM00397
Cosmic-CLP; 1659820
GDSC; 1659820
Lonza; 1318
Ontologies BTO; BTO:0004766
EFO; EFO_0006486
Biological sample resources BioSample; SAMN03473274
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM887564
GEO; GSM888647
GEO; GSM1374868
GEO; GSM1446764
Other Wikidata; Q54952857
Polymorphism and mutation databases Cosmic; 1012054
Cosmic; 1519162
Cosmic; 1633513
Cosmic; 1943610
Cosmic; 2306995
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number22