Cellosaurus SET-2 (CVCL_2187)

Cell line name SET-2
Synonyms Set-2; Set2; SET2
Accession CVCL_2187
Resource Identification Initiative To cite this cell line use: SET-2 (RRID:CVCL_2187)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~60-80 hours (DSMZ).
Sequence variation: Heterozygous for JAK2 p.Val617Phe (PubMed=16408098).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Peripheral blood.
Disease Adult acute megakaryoblastic leukemia (NCIt: C7965)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10
D13S3178,10
D16S5399,10
D18S5113,16
D21S1130
D3S135814,16
D5S81811
D7S82010,12
D8S117913,14
FGA19,23
Penta D11
Penta E16,20
TH017,9.3
TPOX8
vWA14,17
Publications

PubMed=10637490; DOI=10.1038/sj.leu.2401608
Uozumi K., Otsuka M., Ohno N., Moriyama T., Suzuki S., Shimotakahara S., Matsumura I., Hanada S., Arima T.
Establishment and characterization of a new human megakaryoblastic cell line (SET-2) that spontaneously matures to megakaryocytes and produces platelet-like particles.
Leukemia 14:142-152(2000)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Cross-references
Cell line collections DSMZ; ACC-608
Cell line databases/resources CCLE; SET2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cosmic-CLP; 1659820
GDSC; 1659820
Ontologies BTO; BTO:0004766
EFO; EFO_0006486
Biological sample resources BioSample; SAMN03473274
Gene expression databases GEO; GSM887564
GEO; GSM888647
GEO; GSM1374868
GEO; GSM1446764
Polymorphism and mutation databases Cosmic; 1012054
Cosmic; 1519162
Cosmic; 1633513
Cosmic; 1943610
Cosmic; 2306995