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Cellosaurus SiSo (CVCL_2193)

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Cell line name SiSo
Synonyms SISO
Accession CVCL_2193
Resource Identification Initiative To cite this cell line use: SiSo (RRID:CVCL_2193)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 24 hours (PubMed=21556646); ~35 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for KRAS p.Gly12Asp (c.35G>A) (CCLE; Cosmic-CLP).
Homozygous for RB1 p.Ser834Ter (c.2501C>G) (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African3.91
Native American0.11
East Asian, North79.2
East Asian, South9.59
South Asian0
European, North0
European, South7.19
Disease Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,12
D2S133819
D3S135815
D5S8189,12
D7S82011,12
D8S117912
D13S31711
D16S5399
D18S5114,16
D19S43314,16.2
D21S1130,31
FGA23
Penta D11,13
Penta E11,13
TH017,9 (Cosmic-CLP; DSMZ)
7 (PubMed=25877200)
TPOX11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=21556646; DOI=10.3892/ijo.6.5.1099
Sonoda K., Nakashima M., Saito T., Amada S., Kamura T., Nakano H., Watanabe T.
Establishment of a new human uterine cervical adenocarcinoma cell-line, SiSo, and its reactivity to anticancer reagents.
Int. J. Oncol. 6:1099-1104(1995)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections DSMZ; ACC-327
Cell line databases/resources CCLE; SISO_CERVIX
Cell_Model_Passport; SIDM00394
Cosmic-CLP; 1240212
DepMap; ACH-001650
LINCS_LDP; LCL-1514
Ontologies CLO; CLO_0009021
Biological sample resources BioSample; SAMN03470956
BioSample; SAMN03473350
Chemistry resources ChEMBL-Cells; CHEMBL3307272
ChEMBL-Targets; CHEMBL613527
GDSC; 1240212
PharmacoDB; SISO_1379_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM1670424
Other Wikidata; Q54953520
Polymorphism and mutation databases Cosmic; 1995628
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number22