Cellosaurus SK-GT-4 (CVCL_2195)

Cell line name SK-GT-4
Synonyms SKGT4
Accession CVCL_2195
Resource Identification Initiative To cite this cell line use: SK-GT-4 (RRID:CVCL_2195)
Comments From: Memorial Sloan-Kettering Cancer Center; New York; USA.
Doubling time: 39 hours (PubMed=8334620); ~30-35 hours (DSMZ).
Microsatellite instability: Stable (MSS) (Sanger).
Sequence variation: KRAS p.Gly12Asp (DOI=10.12688/f1000research.7033.1).
Sequence variation: TP53 p.Gln100Ter (PubMed=20075370).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: Genome sequenced.
Omics: Transcriptome analysis.
Misspelling: SJGT4; In GEO GSM337727.
Disease Esophageal adenocarcinoma (NCIt: C4025)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DSMZ; PubMed=20075370

Markers:
AmelogeninX
CSF1PO11,15
D13S3179,10
D16S53911,12,13
D18S5114
D21S1131.2
D3S135817
D5S81812
D7S8207,11
D8S117913
FGA22,23
Penta D9
Penta E7
TH016,9.3
TPOX8,10
vWA17,19
Publications

PubMed=8334620; DOI=10.1002/1097-0142(19930801)72:3<649::AID-CNCR2820720305>3.0.CO;2-L
Altorki N., Schwartz G.K., Blundell M., Davis B.M., Kelsen D.P., Albino A.P.
Characterization of cell lines established from human gastric-esophageal adenocarcinomas. Biologic phenotype and invasion potential.
Cancer 72:649-657(1993)

PubMed=11520067; DOI=10.1006/bbrc.2001.5400
Kan T., Shimada Y., Sato F., Maeda M., Kawabe A., Kaganoi J.-I., Itami A., Yamasaki S., Imamura M.
Gene expression profiling in human esophageal cancers using cDNA microarray.
Biochem. Biophys. Res. Commun. 286:792-801(2001)

PubMed=20075370; DOI=10.1093/jnci/djp499
Boonstra J.J., van Marion R., Beer D.G., Lin L., Chaves P., Ribeiro C., Pereira A.D., Roque L., Darnton S.J., Altorki N.K., Schrump D.S., Klimstra D.S., Tang L.H., Eshleman J.R., Alvarez H., Shimada Y., van Dekken H., Tilanus H.W., Dinjens W.N.M.
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.
J. Natl. Cancer Inst. 102:271-274(2010)

PubMed=20139130; DOI=10.1093/carcin/bgq036
Duggan S.P., Behan F.M., Kirca M., Smith S.M., Reynolds J.V., Long A., Kelleher D.P.
An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-kappaB activation and cytokine levels.
Carcinogenesis 31:936-945(2010)

PubMed=23795680; DOI=10.1111/dote.12095
Boonstra J.J., Tilanus H.W., Dinjens W.N.M.
Translational research on esophageal adenocarcinoma: from cell line to clinic.
Dis. Esophagus 28:90-96(2015)

DOI=10.12688/f1000research.7033.1
Contino G., Eldridge M.D., Secrier M., Bower L., Elliott R.F., Weaver J., Lynch A.G., Edwards P.A.W., Fitzgerald R.C.
Whole-genome sequencing of nine esophageal adenocarcinoma cell lines.
F1000Research 5:1336-1336(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections DSMZ; ACC-712
ECACC; 11012007
Cell line databases/resources Cosmic-CLP; 1503365
GDSC; 1503365
Ontologies EFO; EFO_0001237
Biological sample resources BioSample; SAMN03473395
Gene expression databases GEO; GSE2144
GEO; GSE13376
GEO; GSM1374878
GEO; GSM1670431
Polymorphism and mutation databases Cosmic; 1599346