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Cellosaurus TFK-1 (CVCL_2214)

[Text version]

Cell line name TFK-1
Synonyms TFK1
Accession CVCL_2214
Resource Identification Initiative To cite this cell line use: TFK-1 (RRID:CVCL_2214)
Comments Doubling time: ~37 hours, at 40th passage (PubMed=8693487); ~40 hours (DSMZ).
Omics: Deep exome analysis.
Misspelling: TFKK-1; PubMed=22490663 supplementary figure 2.
Sequence variations Homozygous for TP53 p.Trp91Ter (c.272G>A) (DepMap).
Disease Cholangiocarcinoma (NCIt: C4436)
Cholangiocarcinoma (ORDO: Orphanet_70567)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_QZ53 (RTFK-1)
Sex of cell Male
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): DSMZ; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO10
D5S8189,12
D7S82010 (DSMZ)
10,11 (RCB; TKG)
D13S31714
D16S5399
TH016
TPOX8
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=8693487; DOI=10.1620/tjem.177.61
Saijyo S., Kudo T., Suzuki M., Katayose Y., Shinoda M., Muto T., Fukuhara K., Suzuki T., Matsuno S.
Establishment of a new extrahepatic bile duct carcinoma cell line, TFK-1.
Tohoku J. Exp. Med. 177:61-71(1995)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=22490663; DOI=10.1016/j.bbrc.2012.03.122
Saiki Y., Yoshino Y., Fujimura H., Manabe T., Kudo Y., Shimada M., Mano N., Nakano T., Lee Y., Shimizu S., Oba S., Fujiwara S., Shimizu H., Chen N., Nezhad Z.K., Jin G., Fukushige S., Sunamura M., Ishida M., Motoi F., Egawa S., Unno M., Horii A.
DCK is frequently inactivated in acquired gemcitabine-resistant human cancer cells.
Biochem. Biophys. Res. Commun. 421:98-104(2012)

CLPUB00275
Zach S., Birgin E., Ruckert F.
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442
Saha S.K., Gordan J.D., Kleinstiver B.P., Vu P., Najem M.S., Yeo J.-C., Shi L., Kato Y., Levin R.S., Webber J.T., Damon L.J., Egan R.K., Greninger P., McDermott U., Garnett M.J., Jenkins R.L., Rieger-Christ K.M., Sullivan T.B., Hezel A.F., Liss A.S., Mizukami Y., Goyal L., Ferrone C.R., Zhu A.X., Joung J.K., Shokat K.M., Benes C.H., Bardeesy N.
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 6:727-739(2016)

PubMed=31077409; DOI=10.1002/hep.30704
Sittithumcharee G., Suppramote O., Vaeteewoottacharn K., Sirisuksakun C., Jamnongsong S., Laphanuwat P., Suntiparpluacha M., Matha A., Chusorn P., Buraphat P., Kakanaporn C., Charngkaew K., Silsirivanit A., Korphaisarn K., Limsrichamrern S., Tripatara P., Pairojkul C., Wongkham S., Sampattavanich S., Okada S., Jirawatnotai S.
Dependency of cholangiocarcinoma on cyclin D-dependent kinase activity.
Hepatology 70:1614-1630(2019)

Cross-references
Cell line collections DSMZ; ACC-344
RCB; RCB2537
TKG; TKG 0367
Cell line databases/resources Cell_Model_Passport; SIDM01462
DepMap; ACH-001673
Ontologies CLO; CLO_0009330
CLO; CLO_0050010
Biological sample resources BioSample; SAMN03471922
BioSample; SAMN03473356
Other Wikidata; Q54972205
Polymorphism and mutation databases Cosmic; 927187
Cosmic; 1122354
Cosmic; 1373550
Cosmic; 2674051
Entry history
Entry creation04-Apr-2012
Last entry update12-Mar-2020
Version number18