Cellosaurus UT-7 (CVCL_2233)

Cell line name UT-7
Synonyms UT7
Accession CVCL_2233
Resource Identification Initiative To cite this cell line use: UT-7 (RRID:CVCL_2233)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: ~36-48 hours (PubMed=1824823); ~70 hours (DSMZ).
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Bone marrow.
Disease Adult acute megakaryoblastic leukemia (NCIt: C7965)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_5202 (UT-7/Epo); CVCL_5203 (UT-7/GM)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): DSMZ; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO12
D13S3178
D16S53910,12
D18S5114,17
D21S1131.2
D3S135816
D5S81812
D7S8208
D8S117911,15
FGA23
Penta D9,11
Penta E16,17
TH016,9
TPOX10
vWA14,18
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=UT-7
Publications

PubMed=2217443
Miura Y., Komatsu N., Suda T.
Growth and differentiation of two human megakaryoblastic cell lines CMK and UT-7.
Prog. Clin. Biol. Res. 356:259-270(1990)

PubMed=1824823
Komatsu N., Nakauchi H., Miwa A., Ishihara T., Eguchi M., Moroi M., Okada M., Sato Y., Wada H., Yawata Y., Suda T., Miura Y.
Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival.
Cancer Res. 51:341-348(1991)

PubMed=11021758; DOI=10.1038/sj.leu.2401891
Majka M., Rozmyslowicz T., Honczarenko M., Ratajczak J., Wasik M.A., Gaulton G.N., Ratajczak M.Z.
Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines.
Leukemia 14:1821-1832(2000)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

Cross-references
Cell line collections DSMZ; ACC-137
Cell line databases/resources CLDB; cl5398
CCLE; UT7_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
CCRID; 3111C0001CCC000120
Lonza; 41
Ontologies BTO; BTO:0000960
CLO; CLO_0009490
Biological sample resources BioSample; SAMN03472875
Chemistry resources ChEMBL-Cells; CHEMBL3307293
ChEMBL-Targets; CHEMBL614057
Gene expression databases GEO; GSM887730
GEO; GSM888825
GEO; GSM1374979
Polymorphism and mutation databases Cosmic; 787487
Cosmic; 919130
Cosmic; 975312
Cosmic; 1012128
Cosmic; 1281362
Cosmic; 1465951
Cosmic; 2089659